Influence of Hilar Deposition in the Evaluation of the Alveolar Epithelial Permeability on 99mTc-DTPA Aerosol Inhaled Scintigraphy

Overview

Journal Jpn J Radiol

Publisher Springer

Specialty Radiology

Date 2009 Apr 18

PMID 19373527

Citations 1

Authors

Shigeyuki Ogi

Eisuke Gotoh

Mayuki Uchiyama

Kunihiko Fukuda

Mitsuyoshi Urashima

Nobuyoshi Fukumitsu

Affiliations

Soon will be listed here.

Abstract

Purpose: We investigated whether hilar radioaerosol deposition affects the clearance rate of technetium-99m-labeled diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) from peripheral alveolar regions.

Materials And Methods: A total of 38 patients underwent (99m)Tc-DTPA inhalation lung scintigraphy. Six region of interest (ROI) patterns were adopted: ROI 1 was outlined around the entire hemithorax, and ROIs 2-6 were outlined around the hemithorax but excluded square ROIs of different size in the hilar region. Half-times (T(1/2) were calculated with time-activity curves using one-compartment and two-compartment analyses. The T(1/2) of ROIs 1-5 were plotted against the T(1/2) of ROI 6, and regression lines were obtained with the least-squares method. The absolute values of the differences between surveyed values and regression line were calculated. The Wilcoxon test for trend and a single linear regression model were used to determine statistical significance.

Results: There were significant reductions in the absolute values of the differences between surveyed values and regression line from ROIs 1-5 by one-component analysis and the fast component of two-compartment analysis (P < 0.001).

Conclusion: Our results suggest that the deposition of radioaerosol in the hilar region affects the clearance rate of (99m)Tc-DTPA from the alveoli in damaged lungs. The hilar region should be excluded from ROIs when alveolar epithelial permeability is evaluated.

Citing Articles

Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals.

de Albuquerque I, Cardoso D, Masiero P, Paiva D, Resqueti V, Fregonezi G J Bras Pneumol. 2017; 42(6):404-408.

PMID: 28117469 PMC: 5344088. DOI: 10.1590/S1806-37562015000000320.

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