Glucose-6-phosphate Dehydrogenase Deficiency in an Endemic Area for Malaria in Manaus: a Cross-sectional Survey in the Brazilian Amazon

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2009 Apr 17

PMID 19370159

Citations 19

Authors

Marli Stela Santana

Marcus Vinicius Guimaraes de Lacerda

Maria das Gracas Vale Barbosa

Wilson Duarte Alecrim

Maria das Gracas Costa Alecrim

Affiliations

Soon will be listed here.

Abstract

Background: There is a paucity of information regarding glucose-6-phosphate dehydrogenase (G6PD) deficiency in endemic areas for malaria in Latin America.

Methodology/principal Findings: This study determined the prevalence of the G6PD deficiency in 200 male non-consanguineous individuals residing in the Ismail Aziz Community, on the outskirts of Manaus (Brazilian Amazon). Six individuals (3%) were deficient using the qualitative Brewer's test. Gel electrophoresis showed that five of these patients were G6PD A(-). The deficiency was not associated with the ethnic origin (P = 0.571). In a multivariate logistic regression analysis, G6PD deficiency protected against three or more episodes of malaria (P = 0.049), independently of the age, and was associated with a history of jaundice (P = 0.020) and need of blood transfusion (P = 0.045) during previous treatment for malarial infection, independently of the age and the previous malarial exposure.

Conclusions/significance: The frequency of G6PD deficiency was similar to other studies performed in Brazil and the finding of a predominant G6PD A(-) variant will help the clinical management of patients with drug-induced haemolysis. The history of jaundice and blood transfusion during previous malarial infection may trigger the screening of patients for G6PD deficiency. The apparent protection against multiple malarial infections in an area primarily endemic for Plasmodium vivax needs further investigation.

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References

Santana M, da Rocha M, Arcanjo A, Jardim Sardinha J, Alecrim W, Alecrim M . [Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine]. Rev Soc Bras Med Trop. 2007; 40(5):533-6. DOI: 10.1590/s0037-86822007000500008. View

Alecrim M das G, Alecrim W, Macedo V . Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region. Rev Soc Bras Med Trop. 1999; 32(1):67-8. DOI: 10.1590/s0037-86821999000100013. View

Castro S, Weber R, Dadalt V, Tavares V, Giugliani R . Prevalence of G6PD deficiency in newborns in the south of Brazil. J Med Screen. 2006; 13(2):85-6. DOI: 10.1258/096914106777589641. View

De Araujo C, Migot-Nabias F, Guitard J, Pelleau S, Vulliamy T, Ducrocq R . The role of the G6PD AEth376G/968C allele in glucose-6-phosphate dehydrogenase deficiency in the seerer population of Senegal. Haematologica. 2006; 91(2):262-3. View

Weimer T, Salzano F, Westwood B, Beutler E . Molecular characterization of glucose-6-phosphate dehydrogenase variants from Brazil. Hum Biol. 1993; 65(1):41-7. View

Brewer G, TARLOV A, ALVING A . The methemoglobin reduction test for primaquine-type sensitivity of erythrocytes. A simplified procedure for detecting a specific hypersusceptibility to drug hemolysis. JAMA. 1962; 180:386-8. DOI: 10.1001/jama.1962.03050180032008. View

Compri M, Saad S, Ramalho A . [Genetico-epidemiological and molecular investigation of G-6-PD deficiency in a Brazilian community]. Cad Saude Publica. 2000; 16(2):335-42. DOI: 10.1590/s0102-311x2000000200004. View

Forbes J, STEYTLER J, Van Heerden R . Agarose gel electrophoresis of glucose-6-phosphate-dehydrogenase isoenzymes. Clin Chim Acta. 1991; 199(3):279-82. DOI: 10.1016/0009-8981(91)90121-r. View

GREENE L, McMahon L, DiIorio J . Co-evolution of glucose-6-phosphate dehydrogenase deficiency and quinine taste sensitivity. Ann Hum Biol. 1993; 20(5):497-500. DOI: 10.1080/03014469300002892. View

10.

Louicharoen C, Nuchprayoon I . G6PD Viangchan (871G>A) is the most common G6PD-deficient variant in the Cambodian population. J Hum Genet. 2005; 50(9):448-452. DOI: 10.1007/s10038-005-0276-2. View

11.

Goncalves M, Alecrim W . Non-planed urbanization as a contributing factor for malaria incidence in Manaus-Amazonas, Brazil. Rev Salud Publica (Bogota). 2004; 6(2):156-66. DOI: 10.1590/s0124-00642004000200003. View

12.

Saad S, Salles T, Carvalho M, Costa F . Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Brazil. Hum Hered. 1997; 47(1):17-21. DOI: 10.1159/000154383. View

13.

Iwai K, Hirono A, Matsuoka H, Kawamoto F, Horie T, Lin K . Distribution of glucose-6-phosphate dehydrogenase mutations in Southeast Asia. Hum Genet. 2001; 108(6):445-9. DOI: 10.1007/s004390100527. View

14.

Roth Jr E, Raventos-Suarez C, Rinaldi A, Nagel R . Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1983; 80(1):298-9. PMC: 393360. DOI: 10.1073/pnas.80.1.298. View

15.

de Lacerda M, Zackiewicz C, Alecrim W, Alecrim M . The neglected Plasmodium vivax: are researchers from endemic areas really concerned about new treatment options?. Rev Soc Bras Med Trop. 2007; 40(4):489-90. DOI: 10.1590/s0037-86822007000400026. View

16.

Beutler E, Duparc S . Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. Am J Trop Med Hyg. 2007; 77(4):779-89. View

17.

Luzzatto L, Mehta A, Meloni T . Haemoglobinuria and haptoglobin in G6PD deficiency. Br J Haematol. 1995; 91(2):511-2. DOI: 10.1111/j.1365-2141.1995.tb05331.x. View

18.

Usanga E, Ameen R . Glucose-6-phosphate dehydrogenase deficiency in Kuwait, Syria, Egypt, Iran, Jordan and Lebanon. Hum Hered. 2000; 50(3):158-61. DOI: 10.1159/000022906. View

19.

Al-Riyami A, Ebrahim G . Genetic Blood Disorders Survey in the Sultanate of Oman. J Trop Pediatr. 2003; 49 Suppl 1:i1-20. View

20.

Guindo A, Fairhurst R, Doumbo O, Wellems T, Diallo D . X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria. PLoS Med. 2007; 4(3):e66. PMC: 1820604. DOI: 10.1371/journal.pmed.0040066. View