Carotid Stiffness and Microalbuminuria in Patients with Type 2 Diabetes

Overview

Journal Endocrine

Specialty Endocrinology

Date 2009 Apr 16

PMID 19367382

Citations 3

Authors

Wei-Wei Zhan

Yu-Hong Chen

Yi-Fei Zhang

Ying Zhu

Yan-Yan Lin

Xin-Ping Ren

Xiao-Ying Li

Yan-Ping Liu

Affiliations

Soon will be listed here.

Abstract

Microalbuminuria is associated with higher cardiovascular mortality, especially in diabetics. But the direct association between microalbuminuria and vascular wall properties is still not clear. We investigated quantitative carotid stiffness (QCS) index in relation to microalbuminuria in 260 Chinese diabetic patients. In categorical analyses, patients with elevated urinary albumin-to-creatinine ratio (uACR) had higher QCS than those with normal uACR (P < 0.001). The corresponding values for QCS values were 4.4 and 5.9, respectively. In multiple stepwise regression analyses, QCS was significantly associated with age, uACR, plasma glycosylated hemoglobin A(1C) (HbA(1C)), and current smoking (P < 0.05 for all). In conclusion, carotid stiffness as measured by QCS, a local functional measurement of the arterial wall, is increased in type 2 diabetes with microalbuminuria.

Citing Articles

Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?.

Martin-Timon I, Sevillano-Collantes C, Segura-Galindo A, Del Canizo-Gomez F World J Diabetes. 2014; 5(4):444-70.

PMID: 25126392 PMC: 4127581. DOI: 10.4239/wjd.v5.i4.444.

Assessment of carotid arterial wall elasticity in type 2 diabetes mellitus patients with microalbuminuria by real-time ultrasound elastography.

Zhang Y, Gao Y, Su B Int J Endocrinol. 2012; 2012:340974.

PMID: 22693502 PMC: 3369475. DOI: 10.1155/2012/340974.

Approach to lipid screening as a risk marker for cardiovascular disease in pediatric patients with diabetes.

Law J, Patel S, Spagnoli A Front Endocrinol (Lausanne). 2012; 2:47.

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