Medical Bioremediation of Age-related Diseases

Overview

Journal Microb Cell Fact

Publisher Biomed Central

Specialties Biotechnology
Microbiology

Date 2009 Apr 11

PMID 19358742

Citations 3

Authors

Jacques M Mathieu

John Schloendorn

Bruce E Rittmann

Pedro Jj Alvarez

Affiliations

Soon will be listed here.

Abstract

Catabolic insufficiency in humans leads to the gradual accumulation of a number of pathogenic compounds associated with age-related diseases, including atherosclerosis, Alzheimer's disease, and macular degeneration. Removal of these compounds is a widely researched therapeutic option, but the use of antibodies and endogenous human enzymes has failed to produce effective treatments, and may pose risks to cellular homeostasis. Another alternative is "medical bioremediation," the use of microbial enzymes to augment missing catabolic functions. The microbial genetic diversity in most natural environments provides a resource that can be mined for enzymes capable of degrading just about any energy-rich organic compound. This review discusses targets for biodegradation, the identification of candidate microbial enzymes, and enzyme-delivery methods.

Citing Articles

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19.

Ghzaiel I, Sassi K, Zarrouk A, Nury T, Ksila M, Leoni V J Steroid Biochem Mol Biol. 2021; 212:105939.

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Cholesterol Degradation and Production of Extracellular Cholesterol Oxidase from W1 and W8.

Wali H, Rehman F, Umar A, Ahmed S Biomed Res Int. 2019; 2019:1359528.

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Current therapeutic developments in atrophic age-related macular degeneration.

Hanus J, Zhao F, Wang S Br J Ophthalmol. 2015; 100(1):122-7.

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