The Impact of Cellular Networks on Disease Comorbidity

Overview

Journal Mol Syst Biol

Specialty Molecular Biology

Date 2009 Apr 10

PMID 19357641

Citations 132

Authors

Juyong Park

Deok-Sun Lee

Nicholas A Christakis

Albert-Laszlo Barabasi

Affiliations

Soon will be listed here.

Abstract

The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease-gene associations, and population-level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease comorbidity patterns in the human population. Our results indicate that such a combination of population-level data and cellular network information could help build novel hypotheses about disease mechanisms.

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