High-speed Myocardial Perfusion Imaging Initial Clinical Comparison with Conventional Dual Detector Anger Camera Imaging
Overview
Radiology
Authors
Affiliations
Objectives: The purpose of this study was to compare myocardial perfusion imaging (MPI) with high-speed single-photon emission computed tomography (SPECT) with conventional SPECT imaging for the evaluation of myocardial perfusion in patients with known or suspected coronary artery disease.
Background: A novel technology has been developed for high-speed SPECT MPI by employing a bank of independently controlled detector columns with large-hole tungsten collimators and multiple cadmium zinc telluride crystal arrays.
Methods: A total of 44 patients (39 men) underwent same-day Tc-99m sestamibi stress/rest MPI. High-speed SPECT images were performed within 30 min after conventional SPECT. Stress and rest acquisition times were 16 and 12 min for conventional imaging and 4 and 2 min for high-speed SPECT, respectively. Myocardial counts/min (cpm) were calculated for both conventional SPECT and high-speed SPECT. Images were visually analyzed, and the summed stress score (SSS) and summed rest score (SRS) were calculated. Image quality and diagnostic confidence were qualitatively assessed.
Results: High-speed SPECT SSS and SRS correlated linearly with conventional SPECT respective scores (r = 0.93, p < 0.0001 for SSS, and r = 0.93, p < 0.0001 for SRS). Image quality was rated good and higher in 17 (94%) cases for high-speed SPECT and 16 (89%) cases for conventional SPECT. Of the 44 patients studied, 36 (81.8%) and 35 (79.5%) were diagnosed definitely normal or abnormal by conventional and high-speed SPECT, respectively (p = NS). Myocardial count rate was significantly higher in high-speed versus conventional SPECT (384 x 10(-3) +/- 134 x 10(-3) cpm/min vs. 47 x 10(-3) +/- 14 x 10(-3) cpm/min, respectively, p < 0.0001) for stress and (962 x 10(-3) +/- 426 x 10(-3) cpm/min vs. 136 x 10(-3) +/- 37 x 10(-3) cpm/min, respectively, p < 0.001) for rest.
Conclusions: High-speed SPECT provides fast MPI with high image quality and up to 8 times increased system sensitivity. The amount of perfusion abnormality visualized by high-speed SPECT is highly correlated to conventional SPECT, with an equivalent level of diagnostic confidence.
Recent Progress in Myocardial Perfusion Imaging Techniques.
Jo K, Kang W Nucl Med Mol Imaging. 2024; 58(7):400-405.
PMID: 39635632 PMC: 11612050. DOI: 10.1007/s13139-024-00852-7.
Technological Advances in SPECT and SPECT/CT Imaging.
Bouchareb Y, AlSaadi A, Zabah J, Jain A, Al-Jabri A, Phiri P Diagnostics (Basel). 2024; 14(13).
PMID: 39001321 PMC: 11241697. DOI: 10.3390/diagnostics14131431.
Liu B, Yu W, Zhang F, Shi Y, Yang L, Jiang Q Quant Imaging Med Surg. 2023; 13(3):1524-1536.
PMID: 36915324 PMC: 10006131. DOI: 10.21037/qims-22-758.
Hedeer F, Akil S, Oddstig J, Hindorf C, Arheden H, Carlsson M J Nucl Cardiol. 2023; 30(5):1935-1946.
PMID: 36913172 PMC: 10558368. DOI: 10.1007/s12350-022-03185-0.
Jiang Q, Liu B, Yang L, Wang Y, Yu W, Zhang F BMC Cardiovasc Disord. 2023; 23(1):12.
PMID: 36631747 PMC: 9832744. DOI: 10.1186/s12872-023-03051-y.