Directed Ortho Borylation of Functionalized Arenes Catalyzed by a Silica-supported Compact Phosphine-iridium System

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2009 Apr 9

PMID 19351202

Citations 37

Authors

Soichiro Kawamorita

Hirohisa Ohmiya

Kenji Hara

Atsushi Fukuoka

Masaya Sawamura

Affiliations

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Abstract

An immobilized monophosphine-Ir system, which was prepared in situ from [Ir(OMe)(cod)](2) and a silica-supported, compact phosphine, showed high activities and selectivities for the borylation of aromatic C-H bonds with bis(pinacolato)diboron. This system was effective not only for the borylation of benzene but also for the ortho borylation of arenes with directing groups, such as ester, amide, sulfonate, acetal, alkoxymethyl, and chloro groups, under mild reaction conditions.

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