» Articles » PMID: 19350364

Immunological Alterations in Lupus-prone Autoimmune (NZB/NZW) F1 Mice by Mycelia Chinese Medicinal Fungus Cordyceps Sinensis-induced Redistributions of Peripheral Mononuclear T Lymphocytes

Overview
Journal Clin Exp Med
Specialty General Medicine
Date 2009 Apr 8
PMID 19350364
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Mycelia products from wild-form Cordyceps sinensis could be constantly produced in a large scale and would be a better source of this herbal medicine. Our purpose was to investigate the immunological effects of an orally administered hot-water extract cultured mycelium of C. sinensis in lupus-prone (NZB/NZW) F1 hybrids. Forty female mice were divided into four groups and were given 2.4 mg/g/day oral doses of C. sinensis starting at three (group A), six (group B), or eight (group C) months of age, whereas the remaining group (group D) served as a control. Survival, proteinuria, and titers of anti-double-stranded DNA autoantibodies were evaluated. Treatment with C. sinensis resulted in increased survival, decreased proteinuria, and reduced titers of anti-double-stranded DNA antibody in groups A and B. Moreover, the mice in groups A and B showed significantly reduced percentages of CD4(+) T cells (*P < 0.05) and increased percentages of CD8(+) T cells in peripheral blood mononuclear cells (PBMC) after C. sinensis administration. At 6 months of age, the proliferation rate of BrdU-incorporated spleen cells was significantly decreased after 48 and 72 h of C. sinensis treatment (**P < 0.01) in group A of mice. In conclusions, early medication with C. sinensis induced the redistribution of PBMC and attenuated the disease severity of lupus in (NZB/NZW) F1 mice.

Citing Articles

Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway.

Lu T, Zhou L, Chu Z, Song Y, Wang Q, Zhao M Chin Med. 2024; 19(1):54.

PMID: 38528546 PMC: 10962170. DOI: 10.1186/s13020-024-00895-0.


A Review of the Potential Benefits of Herbal Medicines, Small Molecules of Natural Sources, and Supplements for Health Promotion in Lupus Conditions.

Pasdaran A, Hassani B, Tavakoli A, Kozuharova E, Hamedi A Life (Basel). 2023; 13(7).

PMID: 37511964 PMC: 10416186. DOI: 10.3390/life13071589.


spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials.

Das G, Shin H, Leyva-Gomez G, Del Prado-Audelo M, Cortes H, Singh Y Front Pharmacol. 2021; 11:602364.

PMID: 33628175 PMC: 7898063. DOI: 10.3389/fphar.2020.602364.


Clinical and Immunological Response in Dogs Naturally Infected by Treated with a Nutritional Supplement.

Lombardi P, Palatucci A, Giovazzino A, Mastellone V, Ruggiero G, Rubino V Animals (Basel). 2019; 9(8).

PMID: 31366122 PMC: 6721201. DOI: 10.3390/ani9080501.


Hirsutella sinensis mycelium attenuates bleomycin-induced pulmonary inflammation and fibrosis in vivo.

Huang T, Lai H, Ko Y, Ojcius D, Lan Y, Martel J Sci Rep. 2015; 5:15282.

PMID: 26497260 PMC: 4620496. DOI: 10.1038/srep15282.


References
1.
Wofsy D, Seaman W . Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J Exp Med. 1985; 161(2):378-91. PMC: 2187572. DOI: 10.1084/jem.161.2.378. View

2.
Chen Y, Chen S, Ho P, Lin C, Cheng Y, Wang J . Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK. Leuk Res. 2006; 31(6):805-15. DOI: 10.1016/j.leukres.2006.09.016. View

3.
Chen Y, Ye Y, Chiang B . Establishment and characterization of cloned CD4- CD8- alphabeta-T cell receptor (TCR)-bearing autoreactive T cells from autoimmune NZB x NZW F1 mice. Clin Exp Immunol. 1997; 108(1):52-7. PMC: 1904636. DOI: 10.1046/j.1365-2249.1997.d01-971.x. View

4.
Chen J, Yen J, Lin C, Tsai W, Liu W, Tsai J . The effects of Chinese herbs on improving survival and inhibiting anti-ds DNA antibody production in lupus mice. Am J Chin Med. 1993; 21(3-4):257-62. DOI: 10.1142/S0192415X93000303. View

5.
Zhu J, Halpern G, Jones K . The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med. 1999; 4(4):429-57. DOI: 10.1089/acm.1998.4.429. View