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Identification of Ribosomal RNA Genes in Metagenomic Fragments

Overview
Journal Bioinformatics
Publisher Oxford University Press
Specialty Biology
Date 2009 Apr 7
PMID 19346323
Citations 119
Authors
Ying Huang
Paul Gilna
Weizhong Li
Affiliations
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Abstract

Motivation: Identification of genes coding for ribosomal RNA (rRNA) is considered an important goal in the analysis of data from metagenomics projects. Here, we report the development of a software program designed for the identification of rRNA genes from metagenomic fragments based on hidden Markov models (HMMs). This program provides rRNA gene predictions with high sensitivity and specificity on artificially fragmented genomic DNAs.

Availability: Supplementary files, scripts and sample data are available at http://tools.camera.calit2.net/camera/meta_rna.

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