» Articles » PMID: 19342072

Characterization of a Highly Pathogenic Avian Influenza H5N1 Virus Sublineage in Poultry Seized at Ports of Entry into Vietnam

Overview
Journal Virology
Specialty Microbiology
Date 2009 Apr 4
PMID 19342072
Citations 18
Authors
Affiliations
Soon will be listed here.
Abstract

Highly pathogenic avian influenza H5N1 virus was detected in poultry seized at two ports of entry located in Lang Son Province, Vietnam. Sequence analysis of the hemagglutinin (HA) genes from five H5N1 virus isolates and ten PCR amplicons from chicken cloacal samples revealed their close phylogenetic relationship to clade 7 H5N1 HA genes. However, these HA genes exhibited extensive genetic divergence at both the nucleotide and amino acid levels in comparison to previously described clade 7 viruses; e.g., A/chicken/Shanxi/2/2006. In addition, hemagglutination inhibition tests revealed antigenic differences between these and previously isolated H5N1 viruses from Vietnam. These results indicate that viruses with clade 7 HA are evolving rapidly in poultry in Southeast Asia.

Citing Articles

Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.

Escalera-Zamudio M, Golden M, Gutierrez B, Theze J, Keown J, Carrique L Nat Commun. 2020; 11(1):5511.

PMID: 33139731 PMC: 7608645. DOI: 10.1038/s41467-020-19364-x.


Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models.

Belser J, Sun X, Brock N, Pappas C, Pulit-Penaloza J, Zeng H J Virol. 2020; 94(17).

PMID: 32611751 PMC: 7431790. DOI: 10.1128/JVI.00451-20.


Bayesian phylodynamics of avian influenza A virus H9N2 in Asia with time-dependent predictors of migration.

Yang J, Muller N, Bouckaert R, Xu B, Drummond A PLoS Comput Biol. 2019; 15(8):e1007189.

PMID: 31386651 PMC: 6684064. DOI: 10.1371/journal.pcbi.1007189.


Attenuation of highly pathogenic avian influenza A(H5N1) viruses in Indonesia following the reassortment and acquisition of genes from low pathogenicity avian influenza A virus progenitors.

Dharmayanti N, Thor S, Zanders N, Hartawan R, Ratnawati A, Jang Y Emerg Microbes Infect. 2018; 7(1):147.

PMID: 30131494 PMC: 6104089. DOI: 10.1038/s41426-018-0147-5.


Shifting Clade Distribution, Reassortment, and Emergence of New Subtypes of Highly Pathogenic Avian Influenza A(H5) Viruses Collected from Vietnamese Poultry from 2012 to 2015.

Nguyen D, Jang Y, Nguyen T, Jones J, Shepard S, Yang H J Virol. 2016; 91(5).

PMID: 28003481 PMC: 5309939. DOI: 10.1128/JVI.01708-16.