Mechanisms of Endothelial Dysfunction in Obstructive Sleep Apnea

Overview

Journal Vasc Health Risk Manag

Publisher Dove Medical Press

Specialty Cardiology & Vascular Diseases

Date 2009 Apr 2

PMID 19337546

Citations 43

Authors

Amy Atkeson

Sanja Jelic

Affiliations

Soon will be listed here.

Abstract

Endothelial activation and inflammation are important mediators of accelerated atherogenesis and consequent increased cardiovascular morbidity in obstructive sleep apnea (OSA). Repetitive episodes of hypoxia/reoxygenation associated with transient cessation of breathing during sleep in OSA resemble ischemia/reperfusion injury and may be the main culprit underlying endothelial dysfunction in OSA. Additional factors such as repetitive arousals resulting in sleep fragmentation and deprivation and individual genetic susceptibility to vascular manifestations of OSA contribute to impaired endothelial function in OSA. The present review focuses on possible mechanisms that underlie endothelial activation and inflammation in OSA.

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References

Redline S, Tosteson T, Tishler P, Carskadon M, Millman R, Milliman R . Studies in the genetics of obstructive sleep apnea. Familial aggregation of symptoms associated with sleep-related breathing disturbances. Am Rev Respir Dis. 1992; 145(2 Pt 1):440-4. DOI: 10.1164/ajrccm/145.2_Pt_1.440. View

Svatikova A, Wolk R, Wang H, Otto M, Bybee K, Singh R . Circulating free nitrotyrosine in obstructive sleep apnea. Am J Physiol Regul Integr Comp Physiol. 2004; 287(2):R284-7. DOI: 10.1152/ajpregu.00241.2004. View

Danton G, Prado R, Truettner J, Watson B, Dietrich W . Endothelial nitric oxide synthase pathophysiology after nonocclusive common carotid artery thrombosis in rats. J Cereb Blood Flow Metab. 2002; 22(5):612-9. DOI: 10.1097/00004647-200205000-00013. View

Dor Y, Porat R, Keshet E . Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am J Physiol Cell Physiol. 2001; 280(6):C1367-74. DOI: 10.1152/ajpcell.2001.280.6.C1367. View

Boulanger C, Scoazec A, Ebrahimian T, Henry P, Mathieu E, Tedgui A . Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. Circulation. 2001; 104(22):2649-52. DOI: 10.1161/hc4701.100516. View

Jelic S, Padeletti M, Kawut S, Higgins C, Canfield S, Onat D . Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation. 2008; 117(17):2270-8. PMC: 2844329. DOI: 10.1161/CIRCULATIONAHA.107.741512. View

Grebe M, Eisele H, Weissmann N, Schaefer C, Tillmanns H, Seeger W . Antioxidant vitamin C improves endothelial function in obstructive sleep apnea. Am J Respir Crit Care Med. 2006; 173(8):897-901. DOI: 10.1164/rccm.200508-1223OC. View

Maser R, Lenhard M, Rizzo A, Vasile A . Continuous positive airway pressure therapy improves cardiovascular autonomic function for persons with sleep-disordered breathing. Chest. 2007; 133(1):86-91. DOI: 10.1378/chest.07-1580. View

Forsythe J, Jiang B, Iyer N, Agani F, Leung S, Koos R . Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996; 16(9):4604-13. PMC: 231459. DOI: 10.1128/MCB.16.9.4604. View

10.

Kuzkaya N, Weissmann N, Harrison D, Dikalov S . Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem. 2003; 278(25):22546-54. DOI: 10.1074/jbc.M302227200. View

11.

Domoki F, Veltkamp R, Thrikawala N, Robins G, Bari F, Louis T . Ischemia-reperfusion rapidly increases COX-2 expression in piglet cerebral arteries. Am J Physiol. 1999; 277(3):H1207-14. DOI: 10.1152/ajpheart.1999.277.3.H1207. View

12.

Lavie L, Vishnevsky A, Lavie P . Evidence for lipid peroxidation in obstructive sleep apnea. Sleep. 2004; 27(1):123-8. View

13.

Liao J, Zulueta J, Yu F, Peng H, Cote C, Hassoun P . Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest. 1995; 96(6):2661-6. PMC: 185972. DOI: 10.1172/JCI118332. View

14.

Brodsky S, Zhang F, Nasjletti A, Goligorsky M . Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Heart Circ Physiol. 2004; 286(5):H1910-5. DOI: 10.1152/ajpheart.01172.2003. View

15.

Thomas S, Chen K, Keaney Jr J . Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem. 2001; 277(8):6017-24. DOI: 10.1074/jbc.M109107200. View

16.

Greenberg H, Ye X, Wilson D, Htoo A, Hendersen T, Liu S . Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo. Biochem Biophys Res Commun. 2006; 343(2):591-6. DOI: 10.1016/j.bbrc.2006.03.015. View

17.

Drager L, Bortolotto L, Lorenzi M, Figueiredo A, Krieger E, Lorenzi-Filho G . Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med. 2005; 172(5):613-8. DOI: 10.1164/rccm.200503-340OC. View

18.

Mausbach B, Ancoli-Israel S, von Kanel R, Patterson T, Aschbacher K, Mills P . Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer disease. Sleep. 2006; 29(10):1347-52. DOI: 10.1093/sleep/29.10.1347. View

19.

Murata T, Yamawaki H, Hori M, Sato K, Ozaki H, Karaki H . Hypoxia impairs endothelium-dependent relaxation in organ cultured pulmonary artery. Eur J Pharmacol. 2001; 421(1):45-53. DOI: 10.1016/s0014-2999(01)01015-9. View

20.

Gami A, Pressman G, Caples S, Kanagala R, Gard J, Davison D . Association of atrial fibrillation and obstructive sleep apnea. Circulation. 2004; 110(4):364-7. DOI: 10.1161/01.CIR.0000136587.68725.8E. View