Neuropsychological Features in Primary Hyperparathyroidism: a Prospective Study

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2009 Apr 2

PMID 19336505

Citations 36

Authors

Marcella D Walker

Donald J McMahon

William B Inabnet

Ronald M Lazar

Ijeoma Brown

Susan Vardy

Felicia Cosman

Shonni J Silverberg

Affiliations

Soon will be listed here.

Abstract

Context: Data regarding the presence, extent, and reversibility of psychological and cognitive features of primary hyperparathyroidism (PHPT) are conflicting.

Objective: This study evaluated psychological symptoms and cognitive function in PHPT.

Design: This is a case-control study in which symptoms and their improvement 6 months after surgical cure of PHPT were assessed.

Settings: The study was conducted in a university hospital metabolic bone disease unit and endocrine surgery practice.

Participants: Thirty-nine postmenopausal women with PHPT and 89 postmenopausal controls without PHPT participated in the study.

Intervention: Participants with PHPT underwent parathyroidectomy.

Outcome Measures: Measurements used in the study were: Beck Depression Inventory (BDI); State-Trait Anxiety Inventory, Form Y (STAI-Y); North American Adult Reading Test (NAART); Wechsler Memory Scale Logical Memory Test, Russell revision (LM); Buschke Selective Reminding Test (SRT); Rey Visual Design Learning Test (RVDLT); Booklet Category Test, Victoria revision (BCT); Rosen Target Detection Test (RTD); Wechsler Adult Intelligence Scale-Revised Digit Symbol Subtest (DSy); Wechsler Adult Intelligence Scale Digit Span Subtest (DSpan).

Results: At baseline, women with PHPT had significantly higher symptom scores for depression and anxiety than controls and worse performance on tests of verbal memory (LM and SRT) and nonverbal abstraction (BCT). Depressive symptoms, nonverbal abstraction, and some aspects of verbal memory (LM) improved after parathyroidectomy to the extent that scores in these domains were no longer different from controls. Baseline differences and postoperative improvement in cognitive measures were independent of anxiety and depressive symptoms and were not linearly associated with serum levels of calcium or PTH.

Conclusions: Mild PHPT is associated with cognitive features affecting verbal memory and nonverbal abstraction that improve after parathyroidectomy.

Citing Articles

Risk of neuropsychiatric disorders in primary hyperparathyroidism: Parathyroidectomy versus nonoperative management.

Song Z, Balachandra S, Wu C, Wang R, Zmijewski P, Gillis A World J Surg. 2024; 49(1):106-114.

PMID: 39004613 PMC: 11710999. DOI: 10.1002/wjs.12285.

Secondary Hyperparathyroidism and Cognitive Decline.

Crepeau P, Fedorova T, Morris-Wiseman L, Mathur A Curr Transplant Rep. 2024; 10(2):60-68.

PMID: 38707996 PMC: 11068066. DOI: 10.1007/s40472-023-00394-5.

Machine learning-based prediction models for parathyroid carcinoma using pre-surgery cognitive function and clinical features.

Wang Y, Wei B, Zhao T, Shen H, Liu X, Wang J Sci Rep. 2023; 13(1):19007.

PMID: 37923800 PMC: 10624903. DOI: 10.1038/s41598-023-46294-7.

PTH levels, sleep quality, and cognitive function in primary hyperparathyroidism.

Wang Y, Xin Y, Zhao T, Shen H, Liu X, Wang J Endocrine. 2023; 81(2):379-387.

PMID: 37266901 DOI: 10.1007/s12020-023-03410-x.

Successful parathyroidectomy improves cognition in patients with primary hyperparathyroidism: A prospective study in a tertiary medical center and comprehensive review of the literature.

Szalat A, Tamir N, Mazeh H, Newman J Front Endocrinol (Lausanne). 2023; 13:1095189.

PMID: 36619573 PMC: 9813845. DOI: 10.3389/fendo.2022.1095189.

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