Impact of Deoxynivalenol on the Intestinal Microflora of Pigs

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2009 Apr 1

PMID 19333431

Citations 49

Authors

Yann J Wache

Charlotte Valat

Gilbert Postollec

Stephanie Bougeard

Christine Burel

Isabelle P Oswald

Philippe Fravalo

Affiliations

Soon will be listed here.

Abstract

Deoxynivalenol (DON), a mycotoxin produced by some Fusarium species, is a frequent contaminant of cereal. In the present study, 24 weanling piglets received either control feed or feed naturally contaminated with DON (2.8 mg/kg) for four weeks. Consumption of contaminated feed significantly reduced the animal weight gain during the first week of the experiment, but had a moderate effect on cultivable bacteria in the pig intestine. By contrast, changes in the intestinal microflora were observed by Capillary Electrophoresis Single-Stranded Conformation Polymorphism (CE-SSCP) in DON-exposed animals, suggesting an impact of this toxin on the dynamics of intestinal bacteria communities.

Citing Articles

Mitigation effects of plant carbon black on intestinal morphology, inflammation, antioxidant status, and microbiota in piglets challenged with deoxynivalenol.

Wu J, Wang H, Liao J, Ke L, Lu D, Deng B Front Immunol. 2024; 15:1454530.

PMID: 39315103 PMC: 11416923. DOI: 10.3389/fimmu.2024.1454530.

Nutrition strategies to control post-weaning diarrhea of piglets: From the perspective of feeds.

Tang Q, Lan T, Zhou C, Gao J, Wu L, Wei H Anim Nutr. 2024; 17:297-311.

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Selenomethionine Alleviates Deoxynivalenol-Induced Oxidative Injury in Porcine Intestinal Epithelial Cells Independent of MAPK Pathway Regulation.

Huang Z, Zhong H, Li T, Wang Z, Chen X, Zou T Antioxidants (Basel). 2024; 13(3).

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Adverse associations between maternal deoxynivalenol exposure and birth outcomes: a prospective cohort study in China.

Tan T, Chen T, Zhu W, Gong L, Yan Y, Li Q BMC Med. 2023; 21(1):328.

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Impact of Enniatin and Deoxynivalenol Co-Occurrence on Plant, Microbial, Insect, Animal and Human Systems: Current Knowledge and Future Perspectives.

Valenti I, Tini F, Sevarika M, Agazzi A, Beccari G, Bellezza I Toxins (Basel). 2023; 15(4).

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