The Conserved Sporulation Protein YneE Inhibits DNA Replication in Bacillus Subtilis

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2009 Mar 31

PMID 19329632

Citations 32

Authors

Lilah Rahn-Lee

Boris Gorbatyuk

Ole Skovgaard

Richard Losick

Affiliations

Soon will be listed here.

Abstract

Cells of Bacillus subtilis triggered to sporulate under conditions of rapid growth undergo a marked decrease in chromosome copy number, which was partially relieved by a mutation in the sporulation-induced gene yneE. Cells engineered to express yneE during growth were impaired in viability and produced anucleate cells. We conclude that YneE is an inhibitor of DNA replication.

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