The Host Response and Molecular Pathogenesis Associated with Respiratory Syncytial Virus Infection

Overview

Journal Future Microbiol

Specialties Infectious Diseases
Microbiology

Date 2009 Mar 31

PMID 19327115

Citations 44

Authors

Christine M Oshansky

Wenliang Zhang

Elizabeth Moore

Ralph A Tripp

Affiliations

Soon will be listed here.

Abstract

Since the isolation of respiratory syncytial virus (RSV) in 1956, its significance as an important human pathogen in infants, the elderly and the immunocompromised has been established. Many important mechanisms contributing to RSV infection, replication and disease pathogenesis have been uncovered; however, there is still insufficient knowledge in these and related areas, which must be addressed to facilitate the development of safe and effective vaccines and therapeutic treatments. A better understanding of the molecular pathogenesis of RSV infection, particularly the host-cell response and transcription profiles to RSV infection, is required to advance disease intervention strategies. Substantial information is accumulating regarding how RSV proteins modulate molecular signaling and regulation of cytokine and chemokine responses to infection, molecular signals regulating programmed cell death, and innate and adaptive immune responses to infection. This review discusses RSV manipulation of the host response to infection and related disease pathogenesis.

Citing Articles

Clinical Characteristics of Virologically Confirmed Respiratory Syncytial Virus in English Primary Care: Protocol for an Observational Study of Acute Respiratory Infection.

Hoang U, Agrawal U, Ordonez-Mena J, Marcum Z, Radin J, Araujo A JMIR Res Protoc. 2025; 14:e60669.

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Phylogenetic and phylodynamic analysis of respiratory syncytial virus strains circulating in children less than five years of age in Karachi-Pakistan.

Aziz F, Farooqui N, Abbas T, Javaid M, Rafaqat W, Zhamalbekova A Infect Genet Evol. 2024; 126:105694.

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PMID: 36366494 PMC: 9692685. DOI: 10.3390/v14112396.

Micro-Players of Great Significance-Host microRNA Signature in Viral Infections in Humans and Animals.

Ostrycharz E, Hukowska-Szematowicz B Int J Mol Sci. 2022; 23(18).

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Augmentation of Transcriptomic Data for Improved Classification of Patients with Respiratory Diseases of Viral Origin.

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