The Haemopoietic Stem Cell: Between Apoptosis and Self Renewal

Overview

Journal Yale J Biol Med

Specialty Biology

Date 2009 Mar 28

PMID 19325941

Citations 22

Authors

Faris Q Alenzi

Badi Q Alenazi

Shamweel Y Ahmad

Mohamed L Salem

Ali A Al-Jabri

Richard K H Wyse

Affiliations

Soon will be listed here.

Abstract

Self renewal and apoptosis of haemopoietic stem cells (HSC) represent major factors that determine the size of the haemopoietic cell mass. Changes in self renewal above or below the steady state value of 0.5 will result in either bone marrow expansion or aplasia, respectively. Despite the growing body of research that describes the potential role of HSC, there is still very little information on the mechanisms that govern HSC self renewal and apoptosis. Considerable insight into the role of HSC in many diseases has been gained in recent years. In light of their crucial importance, this article reviews recent developments in the understanding of the molecular, biological, and physiological characteristics of haemopoietic stem cells.

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