Drug Tolerance in Biomembranes: a Spin Label Study of the Effects of Ethanol

Overview

Journal Science

Specialty Science

Date 1977 May 6

PMID 193186

Citations 53

Authors

J H Chin

D B Goldstein

Affiliations

Soon will be listed here.

Abstract

Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.

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