MIC6 Associates with Aldolase in Host Cell Invasion by Toxoplasma Gondii

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2009 Mar 25

PMID 19308454

Citations 18

Authors

Bin Zheng

Ai He

Ming Gan

Zhouya Li

Hualiang He

Ximei Zhan

Affiliations

Soon will be listed here.

Abstract

The transmembrane microneme protein MIC6 and its partner MIC1, MIC4 comprise an adhesive complex that play important roles in host cell attachment by the obligate intracellular parasite Toxoplasma gondii. Successful penetration of host cells by T. gondii depends on coordinated interactions between MICs complex and the parasite's cytoskeleton. We have identified that the carboxy-terminal cytoplasmic domain (C domain) of MIC6 interacts with aldolase and the parasite cytoskeleton. Our finding uncovers new features regarding MIC6-aldolase interactions in host cell invasion by T. gondii.

Citing Articles

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