ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) Polymorphisms in Diffuse Astrocytomas

Overview

Journal Clin Exp Med

Specialty General Medicine

Date 2009 Mar 24

PMID 19306055

Citations 13

Authors

Regislaine Valeria Burim

Silvia Aparecida Teixeira

Benedicto Oscar Colli

Fernanda Maris Peria

Luis Fernando Tirapelli

Suely Kazue Nagahashi Marie

Suzana Maria Fleury Malheiros

Sueli Mieko Oba-Shinjo

Alberto Alain Gabbai

Paulo Andrade Lotufo

Carlos Gilberto Carlotti-Junior

Affiliations

Soon will be listed here.

Abstract

Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.

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