A Genome-wide Survey on Basic Helix-loop-helix Transcription Factors in Rat and Mouse

Overview

Journal Mamm Genome

Specialty Genetics

Date 2009 Mar 24

PMID 19306043

Citations 18

Authors

Xiaodong Zheng

X Zheng

Yong Wang

Y Wang

Qin Yao

Q Yao

Zhe Yang

Z Yang

Keping Chen

K Chen

Affiliations

Soon will be listed here.

Abstract

The basic helix-loop-helix (bHLH) proteins play essential roles in a wide range of developmental processes in higher organisms. bHLH family members have been identified in over 20 organisms, including nematode, fruit fly, and human. Our study identified 114 rat and 14 additional mouse bHLH members in rat and mouse genomes, respectively. Phylogenetic analyses revealed that both rat and mouse had 49, 26, 15, 4, 12, and 4 bHLH members in groups A, B, C, D, E, and F, respectively. Only the rat Mxi1 gene has two copies in the genome. All other rat bHLH genes and all mouse bHLH genes are single-copy genes. The chromosomal distribution pattern of mouse, rat, and human bHLH genes suggests the emergence of some bHLH genes through gene duplication, which probably happened at least before the divergence of vertebrates from invertebrates. The present study provides useful information for future studies using rat as a model animal for mammalian development.

Citing Articles

Identification and Phylogenetic Analysis of Basic Helix-Loop-Helix Genes in the Diamondback Moth.

Zeng Z, Wang Y, Johnson N, Wang G, Yao Q, Chen K J Insect Sci. 2018; 18(3).

PMID: 29901738 PMC: 6007555. DOI: 10.1093/jisesa/iey057.

Global identification, structural analysis and expression characterization of bHLH transcription factors in wheat.

Guo X, Wang J BMC Plant Biol. 2017; 17(1):90.

PMID: 28558686 PMC: 5450219. DOI: 10.1186/s12870-017-1038-y.

Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates.

Bao Y, Xu F, Shimeld S Genome Biol Evol. 2017; 9(4):869-886.

PMID: 28338988 PMC: 5381572. DOI: 10.1093/gbe/evx047.

Genome-wide identification, classification, and functional analysis of the basic helix-loop-helix transcription factors in the cattle, Bos Taurus.

Li F, Liu W Mamm Genome. 2017; 28(5-6):176-197.

PMID: 28299435 DOI: 10.1007/s00335-017-9683-x.

Phylogenetic analysis of basic helix-loop-helix transcription factors in the genome of a typical human-disease vector.

Chen M, Dong Y, Chang R, Ang Q, Zhang R, Wu Y Am J Transl Res. 2016; 8(11):4844-4856.

PMID: 27904685 PMC: 5126327.

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