Role of Plasma Membrane Calcium ATPases in Calcium Clearance from Olfactory Sensory Neurons

Overview

Journal Chem Senses

Publisher Oxford University Press

Specialty Biochemistry

Date 2009 Mar 24

PMID 19304763

Citations 11

Authors

S Ponissery Saidu

S D Weeraratne

M Valentine

R Delay

Judith L Van Houten

Affiliations

Soon will be listed here.

Abstract

Odorants cause Ca(2+) to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca(2+) not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca(2+)-dependent adaptation, Ca(2+) must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. This work focuses on the roles of plasma membrane calcium pumps (PMCAs) through the use of inhibitors and mice missing 1 of the 4 PMCA isoforms (PMCA2). We demonstrate a significant contribution of PMCAs in addition to contributions of the Na(+)/Ca(2+) exchanger and endoplasmic reticulum (ER) calcium pump to the rate of calcium clearance after OSN stimulation. PMCAs in neurons can shape the Ca(2+) signal. We discuss the contributions of the specific PMCA isoforms to the shape of the Ca(2+) transient that controls signaling and adaptation in OSNs.

Citing Articles

Ciliary Ca2+ pumps regulate intraciliary Ca2+ from the action potential and may co-localize with ciliary voltage-gated Ca2+ channels.

Yano J, Wells R, Lam Y, Van Houten J J Exp Biol. 2021; 224(9).

PMID: 33944932 PMC: 9563298. DOI: 10.1242/jeb.232074.

INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons.

Ukhanov K, Uytingco C, Green W, Zhang L, Schurmans S, Martens J J Cell Sci. 2021; 135(5).

PMID: 33771931 PMC: 8126451. DOI: 10.1242/jcs.258364.

Cyclic-nucleotide-gated cation current and Ca2+-activated Cl current elicited by odorant in vertebrate olfactory receptor neurons.

Li R, Ben-Chaim Y, Yau K, Lin C Proc Natl Acad Sci U S A. 2016; 113(40):11078-11087.

PMID: 27647918 PMC: 5056050. DOI: 10.1073/pnas.1613891113.

Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease.

Ferrer I, Garcia-Esparcia P, Carmona M, Carro E, Aronica E, Kovacs G Front Aging Neurosci. 2016; 8:163.

PMID: 27458372 PMC: 4932117. DOI: 10.3389/fnagi.2016.00163.

Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.

Antunes G, Sebastiao A, Simoes de Souza F PLoS One. 2014; 9(8):e105531.

PMID: 25144232 PMC: 4140790. DOI: 10.1371/journal.pone.0105531.

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