Composite S-layer Lipid Structures

Overview

Journal J Struct Biol

Specialties Cell Biology
Molecular Biology

Date 2009 Mar 24

PMID 19303933

Citations 13

Authors

Bernhard Schuster

Uwe B Sleytr

Affiliations

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Abstract

Designing and utilization of biomimetic membrane systems generated by bottom-up processes is a rapidly growing scientific and engineering field. Elucidation of the supramolecular construction principle of archaeal cell envelopes composed of S-layer stabilized lipid membranes led to new strategies for generating highly stable functional lipid membranes at meso- and macroscopic scale. In this review, we provide a state of the art survey how S-layer proteins, lipids, and polysaccharides may be used as basic building blocks for the assembly of S-layer supported lipid membranes. These biomimetic membrane systems are distinguished by a nanopatterned fluidity, enhanced stability and longevity and thus, provide a dedicated reconstitution matrix for membrane-active peptides and transmembrane proteins. Exciting areas for application of composite S-layer membrane systems concern sensor systems involving specific membrane functions.

Citing Articles

Formation of planar hybrid lipid/polymer membranes anchored to an S-layer protein lattice by vesicle binding and rupture.

Czernohlavek C, Schuster B Soft Mater. 2020; 18(4):443-450.

PMID: 33235550 PMC: 7116407. DOI: 10.1080/1539445X.2019.1708753.

Electrochemical Biosensors Based on S-Layer Proteins.

Damiati S, Schuster B Sensors (Basel). 2020; 20(6).

PMID: 32204503 PMC: 7147708. DOI: 10.3390/s20061721.

Formation and characteristics of mixed lipid/polymer membranes on a crystalline surface-layer protein lattice.

Czernohlavek C, Schuster B Biointerphases. 2020; 15(1):011002.

PMID: 31948239 PMC: 7116081. DOI: 10.1116/1.5132390.

S-Layer Protein-Based Biosensors.

Schuster B Biosensors (Basel). 2018; 8(2).

PMID: 29641511 PMC: 6023001. DOI: 10.3390/bios8020040.

Analysis of self-assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus.

Liu J, Falke S, Drobot B, Oberthuer D, Kikhney A, Guenther T Eur Biophys J. 2016; 46(1):77-89.

PMID: 27270294 DOI: 10.1007/s00249-016-1139-9.

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