Advances in Genetic Studies of Attention-deficit/hyperactivity Disorder

Overview

Journal Curr Psychiatry Rep

Publisher Current Science

Specialty Psychiatry

Date 2009 Mar 24

PMID 19302768

Citations 15

Authors

Alicia K Smith

Eric Mick

Stephen V Faraone

Affiliations

Soon will be listed here.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is among the most common childhood-onset psychiatric disorders. Although family, twin, and adoption studies demonstrate that ADHD is a highly heritable condition, studies also suggest that genetic architecture is complex, prompting the use of more advanced methodologies such as genome-wide linkage and association studies. Although such studies are theoretically compelling, replication of these results has been inconsistent. Meta-analyses have produced more reliable results, but the associations identified to date account for only a small percentage of the genetic component of ADHD. Approaches such as neuroimaging genetics and epigenetic studies are being explored to probe further the etiologic complexity of this disorder.

Citing Articles

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Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain.

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Inflammation, Anxiety, and Stress in Attention-Deficit/Hyperactivity Disorder.

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Epigenetic Programming by Maternal Behavior in the Human Infant.

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