Stimulation of Anti-RNP Antibody Binding to Cultured Keratinocytes by Estradiol

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1991 Jan 1

PMID 1929544

Citations 3

Authors

F Furukawa

S Imamura

D A Norris

Affiliations

Soon will be listed here.

Abstract

Antibodies to extractable nuclear antigens (ENA) are frequently demonstrated in the serum of patients with cutaneous lupus erythematosus. To gain a better understanding of the influence of sex hormones on cutaneous lupus, we investigated the in vitro binding of anti-ENA antibodies to cultured human keratinocytes. Estradiol-beta augmented the binding of anti-RNP, anti-SS-A/Ro, and anti-SS-B/La antibodies to cultured cells, but produced no enhancement of the binding of anti-Sm antibodies. In addition, we examined the effects of 16-alpha-hydroxyestrone, a highly estrogenic metabolite, on the binding of anti-ENA antibodies to cultured cells. This agent did not produce any augmentation of binding. Based on these experiments, we discuss the influence of estradiol on cutaneous lupus.

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