Natural Killer Cell Receptors and Their Ligands in Liver Diseases

Overview

Journal Med Mol Morphol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Pathology

Date 2009 Mar 19

PMID 19294486

Citations 14

Authors

Satoshi Yamagiwa

Hiroteru Kamimura

Takafumi Ichida

Affiliations

Soon will be listed here.

Abstract

The liver is a distinctive immune organ with predominant innate immunity, being rich in innate immune cells such as natural killer (NK) cells. In humans, NK cells comprise about 30%-50% of intrahepatic lymphocytes, whereas peripheral blood lymphocytes contain about 5%-20% NK cells. Accumulating evidence suggests that NK cells play an important role not only in host defense against invading microorganisms and tumor transformation in the liver but also in liver injury and repair. In recent years, significant progress has been made in terms of understanding how NK cells recognize their target cells and carry out their effector functions. It is now clear that NK cells are strictly regulated by numerous activating and inhibitory NK cell receptors that recognize various classes of cell surface ligands, some of which are expressed by normal healthy cells. Therefore, to further elucidate the involvement of NK cells in the pathogenesis of liver diseases, an understanding of recent advances in NK cell biology is crucial. This review provides an overview of recent advances in our knowledge of human NK cell receptors and their ligands in the context of liver diseases.

Citing Articles

Dynamic immune cell profiling identified natural killer cell shift as the key event in early allograft dysfunction after liver transplantation.

Lu D, Yang X, Pan L, Lian Z, Tan W, Zhuo J Cell Prolif. 2023; 57(4):e13568.

PMID: 37905596 PMC: 10984105. DOI: 10.1111/cpr.13568.

Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model.

Fahrner R, Groger M, Settmacher U, Mosig A BMC Res Notes. 2023; 16(1):285.

PMID: 37865791 PMC: 10590007. DOI: 10.1186/s13104-023-06575-w.

Different distribution of mucosal-associated invariant T cells within the human cecum and colon.

Hama I, Tominaga K, Yamagiwa S, Setsu T, Kimura N, Kamimura H Cent Eur J Immunol. 2019; 44(1):75-83.

PMID: 31114440 PMC: 6526592. DOI: 10.5114/ceji.2019.84020.

On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C.

Chu P, Nakamoto N, Taniki N, Ojiro K, Amiya T, Makita Y PLoS One. 2017; 12(6):e0179096.

PMID: 28617830 PMC: 5472371. DOI: 10.1371/journal.pone.0179096.

Role of NK, NKT cells and macrophages in liver transplantation.

Fahrner R, Dondorf F, Ardelt M, Settmacher U, Rauchfuss F World J Gastroenterol. 2016; 22(27):6135-44.

PMID: 27468206 PMC: 4945975. DOI: 10.3748/wjg.v22.i27.6135.

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