MicroRNA in Cell Differentiation and Development

Overview

Journal Sci China C Life Sci

Specialty Biology

Date 2009 Mar 19

PMID 19294345

Citations 28

Authors

Yi Shi

Youxin Jin

Affiliations

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Abstract

The regulation of gene expression by microRNAs (miRNAs) is a recently discovered pattern of gene regulation in animals and plants. MiRNAs have been implicated in various aspects of animal development and cell differentiation, such as early embryonic development, neuronal development, muscle development, and lymphocyte development, by the analysis of genetic deletions of individual miRNAs in mammals. These studies show that miRNAs are key regulators in animal development and are potential causes of human diseases. Here we review some recent discoveries about the functions of miRNAs in cell differentiation and development.

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