Optical Properties of the Breast During Spontaneous and Birth Control Pill-mediated Menstrual Cycles

Overview

Journal Lasers Med Sci

Publisher Springer

Date 2009 Mar 18

PMID 19291352

Citations 4

Authors

Michele C Stahel

Martin Wolf

Ana Banos

R Hornung

Affiliations

Soon will be listed here.

Abstract

Mastodynia is correlated with the menstrual cycle. Using frequency-domain near-infrared spectroscopy (FD-NIRS), we investigated changes in breast perfusion in women who were or were not using hormonal contraception. Healthy volunteers, on or not on hormonal contraception, were examined. Optical properties were measured in all quadrants of both breasts, and physiological parameters were calculated. Measurements were repeated every other day during one complete menstrual cycle. Measurements were comparable in all quadrants. Data remained unchanged during the entire cycle in patients using hormonal contraception. However, a biphasic variation of deoxyhemoglobin, oxyhemoglobin, total hemoglobin (tHb), and water content (H(2)O) was observed in women not using contraception. tHb and H(2)O distinctly increased during the ovulation period and remained elevated throughout the luteal phase. It was concluded that FD-NIRS allows accurate measurement of optical properties of human breasts. As opposed to the menstrual cycles of persons using oral contraception, spontaneous menstrual cycles exhibit biphasic variations of tissue perfusion parameters. These findings are important for the investigation of mastodynia.

Citing Articles

Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited].

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PMID: 37497520 PMC: 10368025. DOI: 10.1364/BOE.484044.

Effect of menstrual cycle phase on background parenchymal uptake at molecular breast imaging.

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Frequency-domain near-infrared spectroscopy of the uterine cervix during regular pregnancies.

Hornung R, Spichtig S, Banos A, Stahel M, Zimmermann R, Wolf M Lasers Med Sci. 2010; 26(2):205-12.

PMID: 20814712 DOI: 10.1007/s10103-010-0832-7.

Characterizing accuracy of total hemoglobin recovery using contrast-detail analysis in 3D image-guided near infrared spectroscopy with the boundary element method.

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