The Transition from Ductal Carcinoma in Situ to Invasive Breast Cancer: the Other Side of the Coin

Overview

Journal Breast Cancer Res

Specialty Oncology

Date 2009 Mar 18

PMID 19291276

Citations 26

Authors

Stuart J Schnitt

Affiliations

Soon will be listed here.

Abstract

The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition from DCIS to invasive cancer is strongly dependent upon alterations in the microenvironment. The potential roles of myoepithelial cells and of stromal-epithelial interaction are of particular interest in this regard.

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