A Mechanism of Efficient G6PD Inhibition by a Molecular Clip

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2009 Mar 14

PMID 19283805

Citations 6

Authors

Michael Kirsch

Peter Talbiersky

Jolanta Polkowska

Frank Bastkowski

Torsten Schaller

Herbert de Groot

Frank-Gerrit Klarner

Thomas Schrader

Affiliations

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Abstract

Triple duty: A synthetic molecular clip traps nicotinamide adenine dinucleotide phosphate (NADP(+); see picture) as well as occupying both the cofactor- and the substrate-binding site in glucose-6-phosphate (G6P) dehydrogenase. This combination of two inhibition mechanisms makes the clip highly effective and selective for this enzyme over other dehydrogenases.

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