Psychopharmacologic Management of Opioid-dependent Women During Pregnancy
Overview
Authors
Affiliations
Illicit drug use during pregnancy presents complex clinical challenges, including reducing drug use and treating psychiatric disorders. Pharmacologic treatment of psychiatric disorders in a pregnant woman requires an evaluation of the balance between potential clinical benefit and the risk of potential neonatal consequences. This study describes psychiatric symptoms in 111 opioid-dependent pregnant women and their prescribed psychotropic medications. Hypomania, generalized anxiety disorder and depression were the most common disorders for which psychiatric symptoms were endorsed. Over half of women studied were prescribed some form of psychoactive medication during pregnancy. Pharmacologic vs. non-pharmacologic treatment approaches in this patient population are discussed.
Intact responses to non-drug rewards in long-term opioid maintenance treatment.
Eikemo M, Lobmaier P, Pedersen M, Kunoe N, Matziorinis A, Leknes S Neuropsychopharmacology. 2019; 44(8):1456-1463.
PMID: 30928994 PMC: 6785711. DOI: 10.1038/s41386-019-0377-9.
Coyle M, Brogly S, Ahmed M, Patrick S, Jones H Nat Rev Dis Primers. 2018; 4(1):47.
PMID: 30467370 DOI: 10.1038/s41572-018-0045-0.
Increasing pregnancy-related use of prescribed opioid analgesics.
Epstein R, Bobo W, Martin P, Morrow J, Wang W, Chandrasekhar R Ann Epidemiol. 2013; 23(8):498-503.
PMID: 23889859 PMC: 3888316. DOI: 10.1016/j.annepidem.2013.05.017.
Kuo C, Schonbrun Y, Zlotnick C, Bates N, Todorova R, Kao J Subst Use Misuse. 2013; 48(14):1498-508.
PMID: 23819737 PMC: 3795848. DOI: 10.3109/10826084.2013.800116.
Benningfield M, Dietrich M, Jones H, Kaltenbach K, Heil S, Stine S Addiction. 2012; 107 Suppl 1:74-82.
PMID: 23106929 PMC: 4315620. DOI: 10.1111/j.1360-0443.2012.04041.x.