Poly (lactic-co-glycolic Acid) As a Controlled Release Delivery Device

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2009 Mar 14

PMID 19283453

Citations 17

Authors

Tee Yong Lim

Chye Khoon Poh

W Wang

Affiliations

Soon will be listed here.

Abstract

Poly (lactic-co-glycolic acid) (PLGA) is a biodegradable polymer used to make resorbable sutures, and is also used in other applications in tissue engineering. Being an artificial polymer, its degradation rate can be tailored to suit its application. It can be easily moulded into structures with suitable mechanical strength and degrades into relatively harmless products in the body. Its adjustable degradation rate also makes it a potentially excellent controlled release delivery device. However, the functionalization of PLGA with bioactive molecules usually requires extensive chemical modification. Chemical modification may compromise the mechanical strength of PLGA and inactivate the bioactive molecules. In this paper, a study is done to investigate the coating of an angiogenic factor on unmodified PLGA suture substrates for the differentiation of human mesenchymal stem cells (hMSC) into endothelial cells (EC). The results show that the method used to anchor vascular endothelial growth factor (VEGF) onto the PLGA surface can enable the gradual release of VEGF from the substrate into solution to induce the differentiation of hMSCs into ECs. Thus, this method can potentially be used to coat PLGA materials like sutures, meshes and scaffolds, rendering them functional as effective controlled release delivery devices for a wide range of bioactive molecules.

Citing Articles

Development of Curcumin-Loaded TiO-Reinforced Chitosan Monofilaments for Biocompatible Surgical Sutures.

Demirci F Polymers (Basel). 2025; 17(4).

PMID: 40006145 PMC: 11859642. DOI: 10.3390/polym17040484.

A Protocol for co-Injecting Cells with Pulverized Fibers for Improved Cell Survival and Engraftment.

Salazar-Puerta A, Ott N, Diaz-Starokozheva L, Das D, Lawrence W, Johnson J Bio Protoc. 2024; 14(22):e5117.

PMID: 39600980 PMC: 11588581. DOI: 10.21769/BioProtoc.5117.

Highly efficient CRISPR/Cas9-mediated exon skipping for recessive dystrophic epidermolysis bullosa.

du Rand A, Hunt J, Samson C, Loef E, Malhi C, Meidinger S Bioeng Transl Med. 2024; 9(4):e10640.

PMID: 39036091 PMC: 11256143. DOI: 10.1002/btm2.10640.

Protective efficacy of GRA12 or GRA7 recombinant proteins encapsulated in PLGA nanoparticles against acute infection in mice.

Sun H, Deng P, Fu Y, Deng J, Xie R, Huang J Front Cell Infect Microbiol. 2023; 13:1209755.

PMID: 37502604 PMC: 10368986. DOI: 10.3389/fcimb.2023.1209755.

Polymeric nanocarriers: A promising tool for early diagnosis and efficient treatment of colorectal cancer.

Haider M, Zaki K, El Hamshary M, Hussain Z, Orive G, Ibrahim H J Adv Res. 2022; 39:237-255.

PMID: 35777911 PMC: 9263757. DOI: 10.1016/j.jare.2021.11.008.

References

Sheridan M, Shea L, Peters M, Mooney D . Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J Control Release. 2000; 64(1-3):91-102. DOI: 10.1016/s0168-3659(99)00138-8. View

Peters M, Polverini P, Mooney D . Engineering vascular networks in porous polymer matrices. J Biomed Mater Res. 2002; 60(4):668-78. DOI: 10.1002/jbm.10134. View

Lee E, Na K, Bae Y . Polymeric micelle for tumor pH and folate-mediated targeting. J Control Release. 2003; 91(1-2):103-13. DOI: 10.1016/s0168-3659(03)00239-6. View

Ennett A, Kaigler D, Mooney D . Temporally regulated delivery of VEGF in vitro and in vivo. J Biomed Mater Res A. 2006; 79(1):176-84. DOI: 10.1002/jbm.a.30771. View

Huang Y, Kaigler D, Rice K, Krebsbach P, Mooney D . Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res. 2005; 20(5):848-57. DOI: 10.1359/JBMR.041226. View

Cornetta K, Smith F . Regulatory issues for clinical gene therapy trials. Hum Gene Ther. 2002; 13(10):1143-9. DOI: 10.1089/104303402320138925. View

Cohen H, Levy R, Gao J, Fishbein I, Kousaev V, Sosnowski S . Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles. Gene Ther. 2000; 7(22):1896-905. DOI: 10.1038/sj.gt.3301318. View

Sharon J, Puleo D . Immobilization of glycoproteins, such as VEGF, on biodegradable substrates. Acta Biomater. 2008; 4(4):1016-23. PMC: 2587396. DOI: 10.1016/j.actbio.2008.02.017. View

Chung H, Kim H, Yoon J, Park T . Heparin immobilized porous PLGA microspheres for angiogenic growth factor delivery. Pharm Res. 2006; 23(8):1835-41. DOI: 10.1007/s11095-006-9039-9. View

10.

Nakamura M, Abe Y, Tokunaga T . Pathological significance of vascular endothelial growth factor A isoform expression in human cancer. Pathol Int. 2002; 52(5-6):331-9. DOI: 10.1046/j.1440-1827.2002.01367.x. View

11.

Oswald J, Boxberger S, Jorgensen B, Feldmann S, Ehninger G, Bornhauser M . Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells. 2004; 22(3):377-84. DOI: 10.1634/stemcells.22-3-377. View

12.

Lee H, Cusick R, Browne F, Kim T, Ma P, Utsunomiya H . Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices. Transplantation. 2002; 73(10):1589-93. DOI: 10.1097/00007890-200205270-00011. View

13.

Backer M, Patel V, Jehning B, Claffey K, Backer J . Surface immobilization of active vascular endothelial growth factor via a cysteine-containing tag. Biomaterials. 2006; 27(31):5452-8. DOI: 10.1016/j.biomaterials.2006.06.025. View

14.

Stella B, Arpicco S, Peracchia M, Desmaele D, Hoebeke J, Renoir M . Design of folic acid-conjugated nanoparticles for drug targeting. J Pharm Sci. 2000; 89(11):1452-64. DOI: 10.1002/1520-6017(200011)89:11<1452::aid-jps8>3.0.co;2-p. View

15.

Quirici N, Soligo D, Caneva L, Servida F, Bossolasco P, Deliliers G . Differentiation and expansion of endothelial cells from human bone marrow CD133(+) cells. Br J Haematol. 2001; 115(1):186-94. DOI: 10.1046/j.1365-2141.2001.03077.x. View

16.

Jackson D . The unfolding tale of PECAM-1. FEBS Lett. 2003; 540(1-3):7-14. DOI: 10.1016/s0014-5793(03)00224-2. View

17.

Steffens G, Yao C, Prevel P, Markowicz M, Schenck P, Noah E . Modulation of angiogenic potential of collagen matrices by covalent incorporation of heparin and loading with vascular endothelial growth factor. Tissue Eng. 2004; 10(9-10):1502-9. DOI: 10.1089/ten.2004.10.1502. View

18.

Bensaid M, Malecaze F, Prats H, Bayard F, Tauber J . Autocrine regulation of bovine retinal capillary endothelial cell (BREC) proliferation by BREC-derived basic fibroblast growth factor. Exp Eye Res. 1989; 48(6):801-13. DOI: 10.1016/0014-4835(89)90065-1. View

19.

Gehling U, Ergun S, Schumacher U, Wagener C, Pantel K, Otte M . In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood. 2000; 95(10):3106-12. View

20.

Perets A, Baruch Y, Weisbuch F, Shoshany G, Neufeld G, Cohen S . Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res A. 2003; 65(4):489-97. DOI: 10.1002/jbm.a.10542. View