RNA-protein Interactions in Hepadnavirus Reverse Transcription

Overview

Journal Front Biosci (Landmark Ed)

Specialty Biology

Date 2009 Mar 11

PMID 19273150

Citations 21

Authors

Jianming Hu

Li Lin

Affiliations

Soon will be listed here.

Abstract

The small DNA genome of hepadnaviruses is replicated by reverse transcription via an RNA intermediate. This RNA "pregenome" contains important signals that control critical steps of viral replication, including RNA packaging, initiation of reverse transcription, and elongation of minus strand DNA, through specific interactions with the viral reverse transcriptase, the capsid protein, and host factors. In particular, the interaction between the viral reverse transcriptase and RNA pregenome requires a host chaperone complex composed of the heat shock protein 90 and its cochaperones.

Citing Articles

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RNA-Binding Motif Protein 24 (RBM24) Is Involved in Pregenomic RNA Packaging by Mediating Interaction between Hepatitis B Virus Polymerase and the Epsilon Element.

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