Features of Cough Variant Asthma and Classic Asthma During Methacholine-induced Brochoconstriction: a Cross-sectional Study

Overview

Journal Cough

Publisher Biomed Central

Date 2009 Mar 11

PMID 19272144

Citations 14

Authors

Hisako Matsumoto

Akio Niimi

Masaya Takemura

Tetsuya Ueda

Masafumi Yamaguchi

Hirofumi Matsuoka

Makiko Jinnai

Kazuo Chin

Michiaki Mishima

Affiliations

Soon will be listed here.

Abstract

Background: Little is known regarding mechanistic and phenotypic differences between cough variant asthma (CVA), presenting with a chronic cough as the sole symptom that responds to bronchodilators, and classic asthma with wheezing during methacholine inhalation. Here we reported airway sensitivity, airway reactivity, and as the main concern, the appearance of cough and wheezes during methacholine inhalation in patients with CVA or classic asthma.

Methods: We cross-sectionally examined the degrees of airway sensitivity, the point where resistance started to increase, and reactivity, the slope of the methacholine-resistance curve, and the appearance of cough and wheezes in steroid-naïve adult patients with classic asthma (n = 58) or CVA (n = 55) while they were continuously inhaling methacholine during simultaneous measurement of respiratory resistance.

Results: Patients with CVA were less sensitive and less reactive to inhaled methacholine and wheezed less frequently but coughed more frequently during methacholine-induced bronchoconstriction than did patients with classic asthma. Multivariate analysis revealed that airway hypersensitivity and lower baseline FEV1/FVC were associated with the appearance of wheezes, whereas a diagnosis of CVA was associated with coughing.

Conclusion: There are mechanistic and phenotypic differences between CVA and classic asthma during methacholine inhalation. Frequent coughing during bronchoconstriction may be a distinctive feature of CVA.

Citing Articles

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PMID: 36227349 DOI: 10.1007/s00408-022-00575-6.

Manifestation of Bronchial Hyperreactivity from Exposure to Heavy and Precious Metal Vapors among the Ore Smeltery Workers of Zveçan, Kosovo.

Maliqi S, Islami P, Iljazi A, Islami H Indian J Community Med. 2022; 46(4):719-722.

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Niimi A J Thorac Dis. 2021; 13(5):3197-3214.

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Retrospective Study of the Effects of Post-nasal Drip Symptoms on Cough Duration.

Nakajima T, Nagano T, Nishimura Y In Vivo. 2021; 35(3):1799-1803.

PMID: 33910865 PMC: 8193296. DOI: 10.21873/invivo.12440.

Suhuang Zhike Capsules for the Treatment of Cough Variant Asthma: A Meta-analysis.

Gu C, Peng W, Wang Z, Xu Y, Han D, Zhou X Evid Based Complement Alternat Med. 2021; 2020:9485746.

PMID: 33488757 PMC: 7790581. DOI: 10.1155/2020/9485746.

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