Modeling Cell Migration in 3D: Status and Challenges

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2009 Mar 6

PMID 19262098

Citations 20

Authors

Rajagopal Rangarajan

Muhammad H Zaman

Affiliations

Soon will be listed here.

Abstract

Cell migration is a multi-scale process that integrates signaling, mechanics and biochemical reaction kinetics. Various mathematical models accurately predict cell migration on 2D surfaces, but are unable to capture the complexities of 3D migration. Additionally, quantitative 3D cell migration models have been few and far between. In this review we look and characterize various mathematical models available in literature to predict cell migration in 3D matrices and analyze their strengths and possible changes to these models that could improve their predictive capabilities.

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