Focal Adhesion: a Focal Point in Current Cell Biology and Molecular Medicine

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2009 Mar 6

PMID 19262093

Citations 58

Authors

Chuanyue Wu

Affiliations

Soon will be listed here.

Abstract

Cell-extracellular matrix (ECM) is an important property of virtually all cells in multi-cellular organisms. Cell-ECM adhesion research, therefore, has broad impact on biology and medicine. Studies over the past three decades have resulted in tremendous advance in our understanding of the molecular basis and functions of cell-ECM adhesion. Here, I focus on some of the general lessons that we have learned from recent studies on cell-ECM adhesion. In addition, I highlight several topics in this rapidly advancing research area. These topics, which include assembly, disassembly and regulation of cell-ECM adhesion structures, the molecular mechanisms of bi-directional signaling through cell-ECM adhesions, and the tissue and organ pathobiology of cell-ECM adhesion, are pertinent to our understanding of cell-ECM adhesion and signaling.

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References

Schwartz M, Schaller M, Ginsberg M . Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol. 1995; 11:549-99. DOI: 10.1146/annurev.cb.11.110195.003001. View

Kadrmas J, Smith M, Clark K, Pronovost S, Muster N, Yates 3rd J . The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol. 2004; 167(6):1019-24. PMC: 2034365. DOI: 10.1083/jcb.200408090. View

Bershadsky A, Ballestrem C, Carramusa L, Zilberman Y, Gilquin B, Khochbin S . Assembly and mechanosensory function of focal adhesions: experiments and models. Eur J Cell Biol. 2005; 85(3-4):165-73. DOI: 10.1016/j.ejcb.2005.11.001. View

Bar-Sagi D, Hall A . Ras and Rho GTPases: a family reunion. Cell. 2000; 103(2):227-38. DOI: 10.1016/s0092-8674(00)00115-x. View

Burridge K, Chrzanowska-Wodnicka M . Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol. 1996; 12:463-518. DOI: 10.1146/annurev.cellbio.12.1.463. View

Larsen M, Artym V, Green J, Yamada K . The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol. 2006; 18(5):463-71. DOI: 10.1016/j.ceb.2006.08.009. View

Fukuda T, Guo L, Shi X, Wu C . CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. J Cell Biol. 2003; 160(7):1001-8. PMC: 2172761. DOI: 10.1083/jcb.200212113. View

Bendig G, Grimmler M, Huttner I, Wessels G, Dahme T, Just S . Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev. 2006; 20(17):2361-72. PMC: 1560411. DOI: 10.1101/gad.1448306. View

El-Aouni C, Herbach N, Blattner S, Henger A, Rastaldi M, Jarad G . Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J Am Soc Nephrol. 2006; 17(5):1334-44. DOI: 10.1681/ASN.2005090921. View

10.

Fassler R, Meyer M . Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev. 1995; 9(15):1896-908. DOI: 10.1101/gad.9.15.1896. View

11.

Qin J, Vinogradova O, Plow E . Integrin bidirectional signaling: a molecular view. PLoS Biol. 2004; 2(6):e169. PMC: 423143. DOI: 10.1371/journal.pbio.0020169. View

12.

Siegel D, Ashton G, Penagos H, Lee J, Feiler H, Wilhelmsen K . Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet. 2003; 73(1):174-87. PMC: 1180579. DOI: 10.1086/376609. View

13.

Sakai T, Li S, Docheva D, Grashoff C, Sakai K, Kostka G . Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 2003; 17(7):926-40. PMC: 196029. DOI: 10.1101/gad.255603. View

14.

Dai C, Stolz D, Bastacky S, St-Arnaud R, Wu C, Dedhar S . Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol. 2006; 17(8):2164-75. DOI: 10.1681/ASN.2006010033. View

15.

Legate K, Montanez E, Kudlacek O, Fassler R . ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol. 2006; 7(1):20-31. DOI: 10.1038/nrm1789. View

16.

Geiger B, Bershadsky A, Pankov R, Yamada K . Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Nat Rev Mol Cell Biol. 2001; 2(11):793-805. DOI: 10.1038/35099066. View

17.

Wu C . PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions. Trends Cell Biol. 2005; 15(9):460-6. DOI: 10.1016/j.tcb.2005.07.002. View

18.

Zhang Y, Chen K, Tu Y, Velyvis A, Yang Y, Qin J . Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J Cell Sci. 2002; 115(Pt 24):4777-86. DOI: 10.1242/jcs.00166. View

19.

Zaidel-Bar R, Milo R, Kam Z, Geiger B . A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci. 2006; 120(Pt 1):137-48. DOI: 10.1242/jcs.03314. View

20.

Yang J, Rayburn H, Hynes R . Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development. 1995; 121(2):549-60. DOI: 10.1242/dev.121.2.549. View