Physical Function in Older Candidates for Renal Transplantation: an Impaired Population

Overview

Journal Clin J Am Soc Nephrol

Specialty Nephrology

Date 2009 Mar 6

PMID 19261824

Citations 39

Authors

Erica L Hartmann

Dalane Kitzman

Michael Rocco

Xiaoyan Leng

Heidi Klepin

Michelle Gordon

Jack Rejeski

Michael Berry

Stephen Kritchevsky

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Although physical function is a major determinant of health outcomes and quality of life in older adults, standard tools for its assessment have not been routinely applied to the fastest growing segment of the kidney transplant candidate population, which is at high risk of comorbidity and disability--people over age 60. The objective of this study was to describe the baseline physical function in older adults with renal failure referred for transplantation and compare them with older adults with other significant comorbidity.

Design, Setting, Participants, & Measurements: An observational sample comparing physical performance in renal transplant candidates over age 60 (Renal Failure) to older people with diastolic heart failure (Heart Failure), chronic obstructive pulmonary disease (COPD), or at high risk for cardiovascular disease (High CV Risk) was studied.

Results: Older people with Renal Failure were significantly impaired by objective measures of physical function, including lower Short Physical Performance Battery, slower gait speed, and lower grip strength.

Conclusions: Older people referred for renal transplantation had poorer physical performance than older adults with other common chronic diseases and may be at high risk for disability while awaiting transplantation.

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References

Kadikar A, Maurer J, Kesten S . The six-minute walk test: a guide to assessment for lung transplantation. J Heart Lung Transplant. 1997; 16(3):313-9. View

Painter P, Hector L, Ray K, Lynes L, Dibble S, Paul S . A randomized trial of exercise training after renal transplantation. Transplantation. 2002; 74(1):42-8. DOI: 10.1097/00007890-200207150-00008. View

Newman A, Simonsick E, Naydeck B, Boudreau R, Kritchevsky S, Nevitt M . Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. JAMA. 2006; 295(17):2018-26. DOI: 10.1001/jama.295.17.2018. View

Guralnik J, Ferrucci L, Simonsick E, Salive M, Wallace R . Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995; 332(9):556-61. PMC: 9828188. DOI: 10.1056/NEJM199503023320902. View

Guralnik J, Ferrucci L, Pieper C, Leveille S, Markides K, Ostir G . Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci. 2000; 55(4):M221-31. DOI: 10.1093/gerona/55.4.m221. View

Budweiser S, Heidtkamp F, Jorres R, Heinemann F, Arzt M, Schroll S . Predictive significance of the six-minute walk distance for long-term survival in chronic hypercapnic respiratory failure. Respiration. 2007; 75(4):418-26. DOI: 10.1159/000109662. View

Kasiske B, Cangro C, Hariharan S, Hricik D, Kerman R, Roth D . The evaluation of renal transplantation candidates: clinical practice guidelines. Am J Transplant. 2002; 1 Suppl 2:3-95. View

Lo D, Chiu E, Jassal S . A prospective pilot study to measure changes in functional status associated with hospitalization in elderly dialysis-dependent patients. Am J Kidney Dis. 2008; 52(5):956-61. DOI: 10.1053/j.ajkd.2008.04.010. View

Tuppin M, Paratz J, Chang A, Seale H, Walsh J, Kermeeen F . Predictive utility of the 6-minute walk distance on survival in patients awaiting lung transplantation. J Heart Lung Transplant. 2008; 27(7):729-34. DOI: 10.1016/j.healun.2008.03.017. View

10.

Ostir G, Kuo Y, Berges I, Markides K, Ottenbacher K . Measures of lower body function and risk of mortality over 7 years of follow-up. Am J Epidemiol. 2007; 166(5):599-605. DOI: 10.1093/aje/kwm121. View

11.

Shah M, Hasselblad V, Gheorghiade M, Adams Jr K, Swedberg K, Califf R . Prognostic usefulness of the six-minute walk in patients with advanced congestive heart failure secondary to ischemic or nonischemic cardiomyopathy. Am J Cardiol. 2001; 88(9):987-93. DOI: 10.1016/s0002-9149(01)01975-0. View

12.

Foy C, Wickley K, Adair N, Lang W, Miller M, Rejeski W . The Reconditioning Exercise and Chronic Obstructive Pulmonary Disease Trial II (REACT II): rationale and study design for a clinical trial of physical activity among individuals with chronic obstructive pulmonary disease. Contemp Clin Trials. 2006; 27(2):135-46. DOI: 10.1016/j.cct.2005.11.011. View

13.

Cesari M, Kritchevsky S, Baumgartner R, Atkinson H, Penninx B, Lenchik L . Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study. Am J Clin Nutr. 2005; 82(2):428-34. DOI: 10.1093/ajcn.82.2.428. View

14.

Cook W, Jassal S . Functional dependencies among the elderly on hemodialysis. Kidney Int. 2008; 73(11):1289-95. DOI: 10.1038/ki.2008.62. View

15.

Blake C, OMeara Y . Subjective and objective physical limitations in high-functioning renal dialysis patients. Nephrol Dial Transplant. 2004; 19(12):3124-9. DOI: 10.1093/ndt/gfh538. View

16.

Mangani I, Cesari M, Kritchevsky S, Maraldi C, Carter C, Atkinson H . Physical exercise and comorbidity. Results from the Fitness and Arthritis in Seniors Trial (FAST). Aging Clin Exp Res. 2006; 18(5):374-80. DOI: 10.1007/BF03324833. View

17.

Painter P, Carlson L, Carey S, Paul S, Myll J . Physical functioning and health-related quality-of-life changes with exercise training in hemodialysis patients. Am J Kidney Dis. 2000; 35(3):482-92. DOI: 10.1016/s0272-6386(00)70202-2. View

18.

DeOreo P . Hemodialysis patient-assessed functional health status predicts continued survival, hospitalization, and dialysis-attendance compliance. Am J Kidney Dis. 1997; 30(2):204-12. DOI: 10.1016/s0272-6386(97)90053-6. View

19.

Rejeski W, Ip E, Marsh A, Miller M, Farmer D . Measuring disability in older adults: the International Classification System of Functioning, Disability and Health (ICF) framework. Geriatr Gerontol Int. 2008; 8(1):48-54. PMC: 5118869. DOI: 10.1111/j.1447-0594.2008.00446.x. View

20.

Danovitch G, Savransky E . Challenges in the counseling and management of older kidney transplant candidates. Am J Kidney Dis. 2006; 47(4 Suppl 2):S86-97. DOI: 10.1053/j.ajkd.2005.12.042. View