OCT4B1 Isoform: the Novel OCT4 Alternative Spliced Variant As a Putative Marker of Stemness

Overview

Journal Mol Hum Reprod

Specialties Molecular Biology
Reproductive Medicine

Date 2009 Mar 5

PMID 19258399

Citations 14

Authors

Spyros I Papamichos

Vassiliki Kotoula

Basil C Tarlatzis

Theodoros Agorastos

Konstantinos Papazisis

Alexandros F Lambropoulos

Affiliations

Soon will be listed here.

Abstract

A novel OCT4 alternative spliced variant (OCT 4B1) is deduced to be the isoform present in 59 hESC lines characterised by the International Stem Cell Initiative (ISCI) rather than OCT4A as previously assumed. The new variant may be a more reliable marker of stemness than OCT4A and studies are needed to test this.

Citing Articles

Ectopic expression of OCT4B1 Decreases Fertility Rate and Changes Sperm Parameters in Transgenic Mice.

Naseri M, Ranaei Pirmardan E, Mowla S, Shamsara M, Movahedin M, Nouri S Iran J Biotechnol. 2022; 20(3):e3019.

PMID: 36381279 PMC: 9618016. DOI: 10.30498/ijb.2022.278266.3019.

Influence of conception and delivery mode on stress response marker and imprinted gene expression related to embryo development: A cohort study.

Argyraki M, Katafigiotis S, Vavilis T, Papadopoulou Z, Tzimagiorgis G, Haidich A Int J Reprod Biomed. 2021; 19(3):217-226.

PMID: 33842818 PMC: 8023003. DOI: 10.18502/ijrm.v19i3.8569.

Deregulation of Stemness-Related Genes in Endometriotic Mesenchymal Stem Cells: Further Evidence for Self-Renewal/Differentiation Imbalance.

Mashayekhi P, Noruzinia M, Khodaverdi S Iran Biomed J. 2020; 24(5):333-9.

PMID: 32429647 PMC: 7392139. DOI: 10.29252/ibj.24.5.328.

OCT4B1 Promoted EMT and Regulated the Self-Renewal of CSCs in CRC: Effects Associated with the Balance of miR-8064/PLK1.

Zhou J, Hu S, Jiang H, Chen Y, Feng J, Chen Z Mol Ther Oncolytics. 2019; 15:7-20.

PMID: 31650021 PMC: 6804455. DOI: 10.1016/j.omto.2019.08.004.

OCT4B regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells.

Meng L, Hu H, Zhi H, Liu Y, Shi F, Zhang L Oncol Lett. 2018; 16(1):522-528.

PMID: 29930717 PMC: 6006504. DOI: 10.3892/ol.2018.8607.