Common and Distinct Amygdala-function Perturbations in Depressed Vs Anxious Adolescents

Overview

Journal Arch Gen Psychiatry

Specialty Psychiatry

Date 2009 Mar 4

PMID 19255377

Citations 136

Authors

Katja Beesdo

Jennifer Y F Lau

Amanda E Guyer

Erin B McClure-Tone

Christopher S Monk

Eric E Nelson

Stephen J Fromm

Michelle A Goldwin

Hans-Ulrich Wittchen

Ellen Leibenluft

Monique Ernst

Daniel S Pine

Affiliations

Soon will be listed here.

Abstract

Context: Few studies directly compare amygdala function in depressive and anxiety disorders. Data from longitudinal research emphasize the need for such studies in adolescents.

Objective: To compare amygdala response to varying attention and emotion conditions among adolescents with major depressive disorder (MDD) or anxiety disorders, relative to adolescents with no psychopathology.

Design: Case-control study.

Setting: Government clinical research institute.

Participants: Eighty-seven adolescents matched on age, sex, intelligence, and social class: 26 with MDD (14 with and 12 without anxiety disorders), 16 with anxiety disorders but no depression, and 45 without psychopathology.

Main Outcome Measures: Blood oxygen level-dependent signal in the amygdala, measured by means of event-related functional magnetic resonance imaging. During imaging, participants viewed facial expressions (neutral, fearful, angry, and happy) while attention was constrained (afraid, hostility, and nose-width ratings) or unconstrained (passive viewing).

Results: Left and right amygdala activation differed as a function of diagnosis, facial expression, and attention condition both when patients with comorbid MDD and anxiety were included and when they were excluded (group x emotion x attention interactions, P < or = .03). Focusing on fearful face-viewing events, patients with anxiety and those with MDD both differed in amygdala responses from healthy participants and from each other during passive viewing. However, both MDD and anxiety groups, relative to healthy participants, exhibited similar signs of amygdala hyperactivation to fearful faces when subjectively experienced fear was rated.

Conclusions: Adolescent MDD and anxiety disorders exhibit common and distinct functional neural correlates during face processing. Attention modulates the degree to which common or distinct amygdala perturbations manifest in these patient groups, relative to healthy peers.

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References

Pine D, Cohen P, Gurley D, Brook J, Ma Y . The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry. 1998; 55(1):56-64. DOI: 10.1001/archpsyc.55.1.56. View

Rauch S, Whalen P, Shin L, McInerney S, Macklin M, Lasko N . Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biol Psychiatry. 2000; 47(9):769-76. DOI: 10.1016/s0006-3223(00)00828-3. View

Beesdo K, Bittner A, Pine D, Stein M, Hofler M, Lieb R . Incidence of social anxiety disorder and the consistent risk for secondary depression in the first three decades of life. Arch Gen Psychiatry. 2007; 64(8):903-12. DOI: 10.1001/archpsyc.64.8.903. View

Kessler R, Berglund P, Demler O, Jin R, Merikangas K, Walters E . Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005; 62(6):593-602. DOI: 10.1001/archpsyc.62.6.593. View

Roberson-Nay R, McClure E, Monk C, Nelson E, Guyer A, Fromm S . Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study. Biol Psychiatry. 2006; 60(9):966-73. DOI: 10.1016/j.biopsych.2006.02.018. View

Shear M, Bjelland I, Beesdo K, Gloster A, Wittchen H . Supplementary dimensional assessment in anxiety disorders. Int J Methods Psychiatr Res. 2007; 16 Suppl 1:S52-64. PMC: 6879087. DOI: 10.1002/mpr.215. View

Krueger R, Caspi A, Moffitt T, Silva P . The structure and stability of common mental disorders (DSM-III-R): a longitudinal-epidemiological study. J Abnorm Psychol. 1998; 107(2):216-27. DOI: 10.1037//0021-843x.107.2.216. View

Lau J, Goldman D, Buzas B, Fromm S, Guyer A, Hodgkinson C . Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biol Psychiatry. 2008; 65(4):349-55. PMC: 2791528. DOI: 10.1016/j.biopsych.2008.08.037. View

LeDoux J . Emotion circuits in the brain. Annu Rev Neurosci. 2000; 23:155-84. DOI: 10.1146/annurev.neuro.23.1.155. View

10.

Weissman M, Wickramaratne P, Nomura Y, Warner V, Pilowsky D, Verdeli H . Offspring of depressed parents: 20 years later. Am J Psychiatry. 2006; 163(6):1001-8. DOI: 10.1176/ajp.2006.163.6.1001. View

11.

Zarahn E, Aguirre G, DEsposito M . A trial-based experimental design for fMRI. Neuroimage. 1997; 6(2):122-38. DOI: 10.1006/nimg.1997.0279. View

12.

Surguladze S, Brammer M, Keedwell P, Giampietro V, Young A, Travis M . A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol Psychiatry. 2005; 57(3):201-9. DOI: 10.1016/j.biopsych.2004.10.028. View

13.

Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P . Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997; 36(7):980-8. DOI: 10.1097/00004583-199707000-00021. View

14.

Krueger R . The structure of common mental disorders. Arch Gen Psychiatry. 1999; 56(10):921-6. DOI: 10.1001/archpsyc.56.10.921. View

15.

Gur R, Ragland J, Moberg P, Turner T, Bilker W, Kohler C . Computerized neurocognitive scanning: I. Methodology and validation in healthy people. Neuropsychopharmacology. 2001; 25(5):766-76. DOI: 10.1016/S0893-133X(01)00278-0. View

16.

Moffitt T, Caspi A, Harrington H, Milne B, Melchior M, Goldberg D . Generalized anxiety disorder and depression: childhood risk factors in a birth cohort followed to age 32. Psychol Med. 2007; 37(3):441-52. DOI: 10.1017/S0033291706009640. View

17.

Pine D, Cohen P, Johnson J, Brook J . Adolescent life events as predictors of adult depression. J Affect Disord. 2002; 68(1):49-57. DOI: 10.1016/s0165-0327(00)00331-1. View

18.

Monk C, Nelson E, McClure E, Mogg K, Bradley B, Leibenluft E . Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. Am J Psychiatry. 2006; 163(6):1091-7. DOI: 10.1176/ajp.2006.163.6.1091. View

19.

Wittchen H, Beesdo K, Bittner A, Goodwin R . Depressive episodes--evidence for a causal role of primary anxiety disorders?. Eur Psychiatry. 2003; 18(8):384-93. DOI: 10.1016/j.eurpsy.2003.10.001. View

20.

Bittner A, Goodwin R, Wittchen H, Beesdo K, Hofler M, Lieb R . What characteristics of primary anxiety disorders predict subsequent major depressive disorder?. J Clin Psychiatry. 2004; 65(5):618-26, quiz 730. DOI: 10.4088/jcp.v65n0505. View