A Notch Updated

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2009 Mar 4

PMID 19255248

Citations 96

Authors

An-Chi Tien

Akhila Rajan

Hugo J Bellen

Affiliations

Soon will be listed here.

Abstract

Cell-cell signaling mediated by the Notch receptor is iteratively involved in numerous developmental contexts, and its dysregulation has been associated with inherited genetic disorders and cancers. The core components of the signaling pathway have been identified for some time, but the study of the modulation of the pathway in different cellular contexts has revealed many layers of regulation. These include complex sugar modifications in the extracellular domain as well as transit of Notch through defined cellular compartments, including specific endosomes.

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