PTH and PTHrP Signaling in Osteoblasts

Overview

Journal Cell Signal

Date 2009 Mar 3

PMID 19249350

Citations 127

Authors

Nabanita S Datta

Abdul B Abou-Samra

Affiliations

Soon will be listed here.

Abstract

The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old players and recent advances in understanding the control of osteoblast proliferation, differentiation and function.

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References

Kong X, Schipani E, Lanske B, Joun H, Karperien M, Defize L . The rat, mouse and human genes encoding the receptor for parathyroid hormone and parathyroid hormone-related peptide are highly homologous. Biochem Biophys Res Commun. 1994; 200(3):1290-9. DOI: 10.1006/bbrc.1994.1591. View

Hirama T, Koeffler H . Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood. 1995; 86(3):841-54. View

McCarthy T, Centrella M, Canalis E . Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology. 1989; 124(3):1247-53. DOI: 10.1210/endo-124-3-1247. View

Wagner E . Functions of AP1 (Fos/Jun) in bone development. Ann Rheum Dis. 2002; 61 Suppl 2:ii40-2. PMC: 1766713. DOI: 10.1136/ard.61.suppl_2.ii40. View

Xiong Y, Zhang H, Beach D . D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell. 1992; 71(3):505-14. DOI: 10.1016/0092-8674(92)90518-h. View

Rouleau M, Mitchell J, Goltzman D . In vivo distribution of parathyroid hormone receptors in bone: evidence that a predominant osseous target cell is not the mature osteoblast. Endocrinology. 1988; 123(1):187-91. DOI: 10.1210/endo-123-1-187. View

Lian J, Stein G, Javed A, van Wijnen A, Stein J, Montecino M . Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord. 2006; 7(1-2):1-16. DOI: 10.1007/s11154-006-9001-5. View

Rey A, Manen D, Rizzoli R, Ferrari S, Caverzasio J . Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells. Bone. 2007; 41(1):59-67. DOI: 10.1016/j.bone.2007.02.031. View

Pestell R, Albanese C, Reutens A, Segall J, Lee R, Arnold A . The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr Rev. 1999; 20(4):501-34. DOI: 10.1210/edrv.20.4.0373. View

10.

Hurley M, Okada Y, Xiao L, Tanaka Y, Ito M, Okimoto N . Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice. Biochem Biophys Res Commun. 2006; 341(4):989-94. DOI: 10.1016/j.bbrc.2006.01.044. View

11.

Wang Y, Liu Y, Buhl K, Rowe D . Comparison of the action of transient and continuous PTH on primary osteoblast cultures expressing differentiation stage-specific GFP. J Bone Miner Res. 2004; 20(1):5-14. DOI: 10.1359/JBMR.041016. View

12.

Mahon M, Shimada M . Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. FEBS Lett. 2005; 579(3):803-7. DOI: 10.1016/j.febslet.2004.12.056. View

13.

Partridge N, Li X, Qin L . Understanding parathyroid hormone action. Ann N Y Acad Sci. 2006; 1068:187-93. DOI: 10.1196/annals.1346.024. View

14.

Sneddon W, Syme C, Bisello A, Magyar C, Rochdi M, Parent J . Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J Biol Chem. 2003; 278(44):43787-96. DOI: 10.1074/jbc.M306019200. View

15.

Otto F, Thornell A, Crompton T, Denzel A, Gilmour K, Rosewell I . Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997; 89(5):765-71. DOI: 10.1016/s0092-8674(00)80259-7. View

16.

MacDonald B, Gallagher J, Russell R . Parathyroid hormone stimulates the proliferation of cells derived from human bone. Endocrinology. 1986; 118(6):2445-9. DOI: 10.1210/endo-118-6-2445. View

17.

Fermor B, Skerry T . PTH/PTHrP receptor expression on osteoblasts and osteocytes but not resorbing bone surfaces in growing rats. J Bone Miner Res. 1995; 10(12):1935-43. DOI: 10.1002/jbmr.5650101213. View

18.

Partridge N, Kemp B, Veroni M, Martin T . Activation of adenosine 3',5'-monophosphate-dependent protein kinase in normal and malignant bone cells by parathyroid hormone, prostaglandin E2, and prostacyclin. Endocrinology. 1981; 108(1):220-5. DOI: 10.1210/endo-108-1-220. View

19.

Gensure R, Gardella T, Juppner H . Parathyroid hormone and parathyroid hormone-related peptide, and their receptors. Biochem Biophys Res Commun. 2005; 328(3):666-78. DOI: 10.1016/j.bbrc.2004.11.069. View

20.

Neer R, Arnaud C, Zanchetta J, Prince R, Gaich G, Reginster J . Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001; 344(19):1434-41. DOI: 10.1056/NEJM200105103441904. View