Path Dependence of Three-phase or Two-phase End Points in Fluid Binary Lipid Mixtures

Overview

Journal J Phys Chem B

Publisher American Chemical Society

Specialty Chemistry

Date 2009 Feb 27

PMID 19243147

Citations 1

Authors

Emily R Lamberson

Lee R Cambrea

Jean-Christophe Rochet

Jennifer S Hovis

Affiliations

Soon will be listed here.

Abstract

The phase behavior of anionic/zwitterionic mixtures can be controlled by tuning the charge state of the anionic lipid. In the case of dioleoylphosphatidic acid (DOPA)/dioleoylphosphatidylcholine (DOPC) mixtures, demixing occurs either when DOPA is protonated or when DOPA(2-):Ca(2+) complexes form. Herein it will be shown that the final end point, a three-phase or two-phase system, depends on the order in which the charge state is manipulated. The facile accessibility of different end points is a clear demonstration of the inherent flexibility of biological systems.

Citing Articles

Adsorption of alpha-synuclein on lipid bilayers: modulating the structure and stability of protein assemblies.

Haque F, Pandey A, Cambrea L, Rochet J, Hovis J J Phys Chem B. 2010; 114(11):4070-81.

PMID: 20187615 PMC: 2855901. DOI: 10.1021/jp1006704.

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