Strong Synergy of Heat and Modulated Electromagnetic Field in Tumor Cell Killing

Overview

Journal Strahlenther Onkol

Specialties Oncology
Radiology

Date 2009 Feb 26

PMID 19240999

Citations 39

Authors

Gabor Andocs

Helmut Renner

Lajos Balogh

Laszlo Fonyad

Csaba Jakab

Andras Szasz

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Hyperthermia is an emerging complementary method in radiooncology. Despite many positive studies and comprehensive reviews, the method is not widely accepted as a combination to radiotherapy. Modulated electrohyperthermia (mEHT; capacitive, electric field modulated, 13.56 MHz) has been used in clinical practice for almost 2 decades in Germany, Austria and Hungary. This in vivo study in nude mice xenograft tumors compares mEHT with "classic" radiative hyperthermia (radHT).

Material And Methods: Nude mice were xenografted with HT29 human colorectal carcinoma cells. 28 mice in four groups with seven animals each and two tumors per animal (totally 56 tumors) were included in the present study: group 1 as untreated control; group 2 treated with radHT at 42 degrees C; group 3 treated with mEHT at identical 42 degrees C; group 4 treated with mEHT at 38 degrees C (by intensively cooling down the tumor). 24 h after treatment, animals were sacrificed and the tumor cross sections studied by precise morphological methods for the respective relative amount of "dead" tumor cells.

Results: The effect of mEHT established a double effect as a synergy between the purely thermal (temperature-dependent) and nonthermal (not directly temperature-dependent) effects. The solely thermal enhancement ratio (TER) of cell killing was shown to be 2.9. The field enhancement ratio (FER) at a constant temperature of 42 degrees C was measured as 3.2. Their complex application significantly increased the therapeutic enhancement to 9.4.

Conclusion: mEHT had a remarkable cancer cell-killing effect in a nude mice xenograft model.

Citing Articles

The Synergy of Thermal and Non-Thermal Effects in Hyperthermic Oncology.

Minnaar C, Szigeti G, Szasz A Cancers (Basel). 2024; 16(23).

PMID: 39682096 PMC: 11639953. DOI: 10.3390/cancers16233908.

Pulsing Addition to Modulated Electro-Hyperthermia.

Szasz A Bioengineering (Basel). 2024; 11(7).

PMID: 39061807 PMC: 11273694. DOI: 10.3390/bioengineering11070725.

"Cold" colorectal cancer faces a bottleneck in immunotherapy.

Liu J, Yang M, Bai J, Liu Z, Wang X World J Gastrointest Oncol. 2023; 15(2):240-250.

PMID: 36908324 PMC: 9994051. DOI: 10.4251/wjgo.v15.i2.240.

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells.

Wust P, Veltsista P, Oberacker E, Yavvari P, Walther W, Bengtsson O Cancers (Basel). 2022; 14(21).

PMID: 36358768 PMC: 9655505. DOI: 10.3390/cancers14215349.

Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer.

Lee Y, Kim S, Cha H, Han J, Choi H, Go E Cancers (Basel). 2022; 14(5).

PMID: 35267579 PMC: 8909844. DOI: 10.3390/cancers14051271.

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