Why Are Tumour Blood Vessels Abnormal and Why is It Important to Know?

Overview

Journal Br J Cancer

Specialty Oncology

Date 2009 Feb 26

PMID 19240721

Citations 286

Authors

J A Nagy

S-H Chang

A M Dvorak

H F Dvorak

Affiliations

Soon will be listed here.

Abstract

Tumour blood vessels differ from their normal counterparts for reasons that have received little attention. We report here that they are of at least six distinct types, we describe how each forms, and, looking forward, encourage the targeting of tumour vessel subsets that have lost their vascular endothelial growth factor-A (VEGF-A) dependency and so are likely unresponsive to anti-VEGF-A therapies.

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