Seevolution: Visualizing Chromosome Evolution
Overview
Affiliations
Summary: Genome evolution underpins all of biology, yet its principles can be difficult to communicate to the non-specialist. To facilitate broader understanding of genome evolution, we have designed an interactive 3D environment that enables visualization of diverse genome evolution processes. The system can intuitively and interactively animate mutation histories involving genome rearrangement, point mutation, recombination, insertion and deletion. Multiple organisms related by a phylogeny can be visualized simultaneously. As methods to infer evolutionary histories of genomes become increasingly complex, visualization of the evolutionary process will not only be useful for communication, but will also serve as an exploratory tool for discovering new patterns of genome evolution.
Availability: The software is licensed under the GNU GPL and available for download from http://seevolution.org.
Pavlopoulos G, Malliarakis D, Papanikolaou N, Theodosiou T, Enright A, Iliopoulos I Gigascience. 2015; 4:38.
PMID: 26309733 PMC: 4548842. DOI: 10.1186/s13742-015-0077-2.
Unraveling genomic variation from next generation sequencing data.
Pavlopoulos G, Oulas A, Iacucci E, Sifrim A, Moreau Y, Schneider R BioData Min. 2013; 6(1):13.
PMID: 23885890 PMC: 3726446. DOI: 10.1186/1756-0381-6-13.
Meander: visually exploring the structural variome using space-filling curves.
Pavlopoulos G, Kumar P, Sifrim A, Sakai R, Lin M, Voet T Nucleic Acids Res. 2013; 41(11):e118.
PMID: 23605045 PMC: 3675473. DOI: 10.1093/nar/gkt254.