Beyond Reppe: Building Substituted Arenes by [2+2+2] Cycloadditions of Alkynes

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2009 Feb 21

PMID 19229917

Citations 23

Authors

Brandon R Galan

Tomislav Rovis

Affiliations

Soon will be listed here.

Abstract

Synthetic sequel: The transition-metal-catalyzed [2+2+2] cycloaddition is an established method for the construction of carbocyclic frameworks but is often plagued by poor selectivity. Recent literature paints a promising picture--a more general metal-catalyzed [2+2+2] cycloaddition can be accomplished intermolecularly using three separate alkynes to furnish highly substituted arenas (see scheme).

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