Calcium-activated Neutral Protease Activities in Brain Trauma

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1991 Apr 1

PMID 1922659

Citations 2

Authors

E Arrigoni

F Cohadon

Affiliations

Soon will be listed here.

Abstract

This paper investigates the level of cytosolic and synaptosomal forms of calcium activated neutral protease activities in the normal brain and their changes following a freezing lesion in the rabbit. From 1 to 24 hours post lesion we observe a progressive disappearing of the enzyme activities from the cytosolic compartment and concurrently their increase in the membranal fraction. These changes are likely to be due to a rise in intracellular calcium concentration, a well documented consequence of many cellular insults. The specific role of the activation of calpain activities in the pathophysiology of trauma is discussed, an enhancement of excitotoxic mechanisms is proposed.

Citing Articles

Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury.

Deng Y, Thompson B, Gao X, Hall E Exp Neurol. 2007; 205(1):154-65.

PMID: 17349624 PMC: 1950332. DOI: 10.1016/j.expneurol.2007.01.023.

Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP.

Saito K, Nixon R Neurochem Res. 1993; 18(2):231-3.

PMID: 8474564 DOI: 10.1007/BF01474689.

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