The Structure of HLA-B27 Reveals Nonamer Self-peptides Bound in an Extended Conformation

Overview

Journal Nature

Specialty Science

Date 1991 Sep 26

PMID 1922337

Citations 156

Authors

D R Madden

J C Gorga

J L Strominger

D C Wiley

Affiliations

Soon will be listed here.

Abstract

X-ray crystallography reveals electron density in the antigen-binding site of HLA-B27 that is an interpretable image of nonameric peptides in a largely extended conformation. Clear density exists for the main chain and several side chains and is consistent with the sequence of 11 nonameric self-peptides eluted from HLA-B27. Pockets in the antigen-binding cleft bind four side chains and the amino and carboxyl termini of the peptide.

Citing Articles

[The role of HLA-B27 in the pathogenesis and diagnosis of axial spondyloarthritis : 50 years after discovery of the strong genetic association].

Braun J, Rudwaleit M, Sieper J Z Rheumatol. 2023; 83(2):125-133.

PMID: 38112753 DOI: 10.1007/s00393-023-01460-0.

Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis.

Braun J, Sieper J RMD Open. 2023; 9(3).

PMID: 37652557 PMC: 10476136. DOI: 10.1136/rmdopen-2023-003102.

Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility.

Talwar J, Laub D, Pagadala M, Castro A, Lewis M, Luebeck G Am J Hum Genet. 2023; 110(7):1138-1161.

PMID: 37339630 PMC: 10357503. DOI: 10.1016/j.ajhg.2023.05.013.

A Highly Complex, MHC-Linked, 350 Million-Year-Old Shark Nonclassical Class I Lineage.

Almeida T, Ohta Y, Gaigher A, Munoz-Merida A, Neves F, Castro L J Immunol. 2021; 207(3):824-836.

PMID: 34301841 PMC: 8454915. DOI: 10.4049/jimmunol.2000851.

50 Years of structural immunology.

Wilson I, Stanfield R J Biol Chem. 2021; 296:100745.

PMID: 33957119 PMC: 8163984. DOI: 10.1016/j.jbc.2021.100745.