Cholera Toxin Requires Oxidized Nicotinamide-adenine Dinucleotide to Activate Adenylate Cyclase in Purified Rat Liver Plasma Membranes

Overview

Journal Biochem J

Specialty Biochemistry

Date 1977 Mar 1

PMID 192202

Citations 8

Authors

B R Martin

M D Houslay

E L Kennedy

Affiliations

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Abstract

Activation of adenylate cyclase in isolated rat liver plasma membranes by cholera toxin was demonstrated. The activation requires the presence of NAD+ and ATP and is irreversible.

Citing Articles

Activation of adenylate cyclase in bovine corpus-luteum membranes by human choriogonadotropin, guanine nucleotides and NaF.

Lydon N, Young J, STANSFIELD D Biochem J. 1981; 198(3):631-8.

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Requirement for guanosine triphosphate for cholera-toxin-catalysed incorporation of adenosine diphosphate ribose into rat liver plasma membranes and for activation of adenylate cyclase.

Doberska C, Macpherson A, Martin B Biochem J. 1980; 186(3):749-54.

PMID: 6446902 PMC: 1161710. DOI: 10.1042/bj1860749.

Mechanism of action of choleragen and E. coli heat-labile enterotoxin: activation of adenylate cyclase by ADP-ribosylation.

Moss J, Vaughan M Mol Cell Biochem. 1981; 37(2):75-90.

PMID: 6268961 DOI: 10.1007/BF02354931.

Islet-activating protein blocks glucagon desensitization in intact hepatocytes.

Heyworth C, Hanski E, Houslay M Biochem J. 1984; 222(1):189-94.

PMID: 6089757 PMC: 1144160. DOI: 10.1042/bj2220189.

Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.

Heyworth C, Whetton A, Wong S, Martin B, Houslay M Biochem J. 1985; 228(3):593-603.

PMID: 3896232 PMC: 1145027. DOI: 10.1042/bj2280593.

References

Sahyoun N, Cuatrecasas P . Mechanism of activation of adenylate cyclase by cholera toxin. Proc Natl Acad Sci U S A. 1975; 72(9):3438-42. PMC: 433009. DOI: 10.1073/pnas.72.9.3438. View

Gill D . Involvement of nicotinamide adenine dinucleotide in the action of cholera toxin in vitro. Proc Natl Acad Sci U S A. 1975; 72(6):2064-8. PMC: 432694. DOI: 10.1073/pnas.72.6.2064. View

Gill D, King C . The mechanism of action of cholera toxin in pigeon erythrocyte lysates. J Biol Chem. 1975; 250(16):6424-32. View

Bennett V, Mong L, Cuatrecasas P . Mechanism of activation of adenylate cyclase by Vibrio cholerae enterotoxin. Relations to the mode of activation by hormones. J Membr Biol. 1975; 24(2):107-29. DOI: 10.1007/BF01868618. View

Houslay M, Metcalfe J, Warren G, Hesketh T, Smith G . The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it. Biochim Biophys Acta. 1976; 436(2):489-94. DOI: 10.1016/0005-2736(76)90210-8. View