Depressed Adolescents Demonstrate Greater Subgenual Anterior Cingulate Activity

Overview

Journal Neuroreport

Specialty Neurology

Date 2009 Feb 17

PMID 19218875

Citations 31

Authors

Tony T Yang

Alan N Simmons

Scott C Matthews

Susan F Tapert

Guido K Frank

Amanda Bischoff-Grethe

Amy E Lansing

Jing Wu

Gregory G Brown

Martin P Paulus

Affiliations

Soon will be listed here.

Abstract

Neuroimaging studies implicate the subgenual anterior cingulate cortex (sgACC) as a critical brain region in adult depression. However, unlike adult depression, little is known about the underlying neural substrates of adolescent depression, and there are no published data examining differences in sgACC activation between depressed and healthy adolescents. This study used functional magnetic resonance imaging to examine sgACC activity in 26 depressed and normal 13-17-year olds during the performance of a stop-signal task. Significantly greater sgACC activation was found in the depressed adolescents relative to controls. These results establish for the first time abnormal functioning of the sgACC in depressed adolescents and have important implications for understanding the underlying neural correlates and potential treatments of adolescent depression.

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