FARP1 Promotes the Dendritic Growth of Spinal Motor Neuron Subtypes Through Transmembrane Semaphorin6A and PlexinA4 Signaling

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2009 Feb 17

PMID 19217374

Citations 56

Authors

BinQuan Zhuang

YouRong Sophie Su

Shanthini Sockanathan

Affiliations

Soon will be listed here.

Abstract

The dendritic morphology of neurons dictates their abilities to process and transmit information; however, the signaling pathways that regulate dendritic growth and complexity are poorly understood. Here, we show that retinoids induce the expression of the FERM Rho-GEF protein FARP1 in the developing spinal cord. FARP1 is expressed in subsets of motor neurons and is enriched in dendrites of lateral motor column (LMC) neurons that innervate the limb. FARP1 is necessary and sufficient to promote LMC dendritic growth but does not affect dendrite number or axonal morphology. We show that FARP1 serves as a specific effector of transmembrane Semaphorin6A and PlexinA4 signals to regulate LMC dendritic growth, and that its Rho-GEF domain is necessary for this function. These findings reveal that retinoid and Sema6A/PlexA4 signaling pathways intersect through FARP1 to control dendritic growth, and uncover the existence of subtype-specific signaling networks that control dendritic developmental programs in spinal motor neurons.

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